56928

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 965557..967382 Replicon chromosome
Accession NZ_CP012667
Organism Vibrio cholerae strain ICDC-VC661

Toxin (Protein)


Gene name hipA Uniprot ID A0A0K9UVP8
Locus tag AN947_RS09975 Protein ID WP_000392003.1
Coordinates 966021..967382 (-) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag AN947_RS09970 Protein ID WP_000804849.1
Coordinates 965557..966024 (-) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN947_RS09955 960837..961541 - 705 WP_001880605.1 NERD domain-containing protein -
AN947_RS09960 961611..964547 - 2937 WP_001283872.1 DEAD/DEAH box helicase family protein -
AN947_RS09965 964551..965129 - 579 WP_000109982.1 class I SAM-dependent methyltransferase -
AN947_RS09970 965557..966024 - 468 WP_000804849.1 helix-turn-helix domain-containing protein Antitoxin
AN947_RS09975 966021..967382 - 1362 WP_000392003.1 type II toxin-antitoxin system HipA family toxin Toxin
AN947_RS09985 967986..968963 + 978 WP_001889101.1 IS481-like element ISVch1 family transposase -
AN947_RS09990 968989..969669 - 681 Protein_834 IS5 family transposase -
AN947_RS09995 970011..971531 - 1521 WP_000640055.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - tcpI / tcpP / tcpH / tcpA / tcpB / tcpQ / tcpC / tcpR / tcpD / tcpS / tcpT / tcpE / tcpF / tcpN/toxT / tcpJ / acfB / acfC / acfA / acfD 960837..1005678 44841
- flank IS/Tn - - 968211..968963 752


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-383)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-138)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51246.17 Da        Isoelectric Point: 4.9109

>T56928 WP_000392003.1 NZ_CP012667:c967382-966021 [Vibrio cholerae]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFIFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSSHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPAGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Download         Length: 1362 bp

>T56928 NZ_CP012667:c967382-966021 [Vibrio cholerae]
ATGGAAGAGCTAACCGTACAAGCTTTTATCAGAGGTGAATGGATAGATATTGGTATCATCTCATTCCCTAAAAGTAGCCA
ACATAATTTTCGAGTGACTGAACTCAACTACCTCAGCGACTATGCGCTAGAACATTACGATAAAGATGACTTTCACGCTG
TTTCACTAAACCACCCTGTCTCATTCATTTTTGATGACATGGGTAAGCCTGGATGGTTAAAGTTTCTAGACGATATTATG
CCTAGTGGCGCTAGTAGACGATACTGGGTCAAACACCTAGATATTGAAGATCTTAGTTCTGATGAACAAGACTATGTTTT
GCTCAAATTTGGCACGATGTCGCCTATTGGTAACTTAAGAATAAAAGACTCCCTTCCTGAACGCTACGAAGTCGCAGACA
ACCTCTACTTCTCTGTTGATGATGTTAAAAATCGAGCAGGTGATTTCCTCGACTATGCACAGCAAAGAGGGGCAGCCGCA
GGTGGTGCAACAGGGGCTGGAGGTGAAGCGCCAAAACTGATCCTCCGATGTGGTTTCGATCATGGATCTGGCAGCGAAAA
AATATGGATTGATCCATACCAAGATGACAATAGCAGCCACGACTTACATTACTTAGTAAAGTACCCTAGAGGCTCAAGAA
GCACCATCGACTGTAATATTCTAAGAGCTGAGTTCTACTTCTACCACGAGCTAACTGAAATGGGAGTTGAAACGATCTCC
ACCGACGGTATGCGCTTGGAGGAAGGATTAAACTACCCTTCCTTATGGCTTCCTCGATTTGATGTTCAAATTATTGATCA
ACAAATAGAGCGATTTGGCATGGAATCAGTGTATTCCATTTTGAACAAAGGCGCTGGAGTCACTCTTGATCACGAAACAA
CAATCCGAACTCTCATAGAAAAAATTACTGAAAGTAATATGGTTAAACACCAAGGGTATAGGTTTGATACCCAAGCTTTC
GTTATTGAATGGGTGAAGAGAGATCTACTCAACATCTTGTTTGGTAATAGTGATAACCATGGCAGAAATACTTCATTCTT
AAAGGGTGATGGAGTCATAAAGCTTGCTCCCATTTACGATTTCGCACCAATGAAAGCCGATCCTGCAGGAATTCCAAGAA
CAACAAAATGGAAAGCCCCACTAGAGGTTGGCGGAACTTACGACTTTGTCGGCATTGCAGACACCTTATCTGATCTGGTG
CCAAAGGAAATGTTATTAAAAGAGCTAGCAATTACTGCAAGTAAATGCGTAGGCCTAAAGCAGAGACTCGCTTTACGAGG
AGTACCAGAACAAATCTTGGAGATGCCGGCCGTTGGACTTAATTATTTATCAGAAAAGCTCACTAAATGGGGGCTACTAT
GA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17095.51 Da        Isoelectric Point: 10.6157

>AT56928 WP_000804849.1 NZ_CP012667:c966024-965557 [Vibrio cholerae]
MKPSNKESVQDTVARLRENRNQQQSKVGKNATHSSKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Download         Length: 468 bp

>AT56928 NZ_CP012667:c966024-965557 [Vibrio cholerae]
ATGAAGCCAAGCAATAAAGAGTCCGTACAAGATACGGTAGCTCGTCTAAGAGAAAACCGAAATCAACAGCAGTCCAAGGT
TGGGAAGAATGCAACTCATTCGAGCAAAGAGCAAACACCACTCGATACTCCAACGAGATCGAAAGCCTCAAAAAACGCCA
AAGCAGTAAGTGCAGCAGAGCGCAAAACCGAGGCAAACAAAATCATCAAACACTTATTGCTTGGAGAGCTAACACAGGGC
CAAGCGCTGAAAAGTCTACGCATTAATATACTGGGACTCAAACAGGATGTATTCGCAAGACTTGTCGATGTCTCAAGAAA
AACACTCTCAGACATAGAGAATGATCGGGGCAGCTACAATACAGAGATTCTCAACAAGGTATTCAAACCATTTAGCTTAA
AAATCGGGCTGCTGCCTTCTTCCCCCGATGCGTTAAAATCGCTCTTAATGGATGGTGAGGATGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UVP8

Antitoxin

Source ID Structure

References