Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 4175454..4175973 Replicon chromosome
Accession NZ_CP012661
Organism Defluviimonas alba strain cai42

Toxin (Protein)


Gene name relE Uniprot ID A0A159Z9G1
Locus tag AKL17_RS19805 Protein ID WP_066816925.1
Coordinates 4175454..4175735 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A159Z7M2
Locus tag AKL17_RS19810 Protein ID WP_066816927.1
Coordinates 4175725..4175973 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AKL17_RS19785 4172124..4173338 + 1215 WP_066816919.1 GTP-binding protein -
AKL17_RS19790 4173340..4173651 + 312 WP_066816920.1 hypothetical protein -
AKL17_RS19795 4173667..4174320 - 654 WP_066816921.1 peroxiredoxin -
AKL17_RS19800 4174455..4175345 - 891 WP_066816923.1 glycosyltransferase family 92 protein -
AKL17_RS19805 4175454..4175735 - 282 WP_066816925.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AKL17_RS19810 4175725..4175973 - 249 WP_066816927.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AKL17_RS25480 4175939..4176082 - 144 WP_166507205.1 hypothetical protein -
AKL17_RS19820 4176535..4177524 - 990 WP_066816929.1 DMT family transporter -
AKL17_RS19825 4177750..4178637 + 888 WP_066816931.1 Na/Pi symporter -
AKL17_RS19830 4178687..4179298 + 612 WP_066816933.1 hypothetical protein -
AKL17_RS19835 4179299..4180408 - 1110 WP_066816939.1 3-isopropylmalate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10761.66 Da        Isoelectric Point: 10.9380

>T56908 WP_066816925.1 NZ_CP012661:c4175735-4175454 [Defluviimonas alba]
MSYELQFLPPALEEWRNLNEPTRLQFKKKLGKVLENPRVPKNKLRGAADRYKIKLRSLGYRLVYEVSATSAVVTVIAVGK
RDKDLVYRAATKR

Download         Length: 282 bp

>T56908 NZ_CP012661:c4175735-4175454 [Defluviimonas alba]
ATGAGCTATGAGTTGCAATTTCTGCCGCCAGCCTTGGAAGAGTGGCGAAATCTGAACGAACCTACTCGGCTTCAGTTCAA
GAAGAAGCTTGGTAAGGTGTTGGAGAACCCGAGGGTCCCCAAAAATAAGCTTAGGGGCGCCGCGGATCGCTACAAGATCA
AGCTGCGCAGCCTTGGATACCGGCTAGTCTACGAGGTTTCGGCTACCAGCGCCGTGGTAACGGTCATTGCTGTTGGCAAG
CGGGACAAGGACCTAGTCTACCGGGCCGCAACCAAGCGCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8921.23 Da        Isoelectric Point: 4.1940

>AT56908 WP_066816927.1 NZ_CP012661:c4175973-4175725 [Defluviimonas alba]
MANLVHAALSASITEFKRNPMAALAQADGESLVVLNHNQPAFYCVPPELYETILDALEDLELNALADQRAGLKPVKVTMD
EL

Download         Length: 249 bp

>AT56908 NZ_CP012661:c4175973-4175725 [Defluviimonas alba]
ATGGCAAATTTGGTCCACGCCGCACTGTCGGCTAGCATCACTGAGTTCAAACGCAACCCAATGGCTGCTTTGGCTCAGGC
GGACGGCGAAAGCCTCGTCGTTCTCAATCATAACCAGCCTGCGTTTTATTGCGTCCCGCCCGAGCTTTATGAGACTATTC
TCGATGCCCTCGAGGATCTGGAGCTTAACGCATTGGCAGACCAGCGCGCAGGCCTAAAGCCTGTGAAAGTCACGATGGAT
GAGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A159Z9G1

Antitoxin

Source ID Structure
AlphaFold DB A0A159Z7M2

References