Detailed information of TA system TA056906

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 173314..173843
• Replicon: chromosome
• Accession: NZ_CP012661
• Organism: Defluviimonas alba strain cai42

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: AKL17_RS00810
• Protein ID: WP_066808674.1
• Coordinates: 173314..173616 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A159YYF8
• Locus tag: AKL17_RS00815
• Protein ID: WP_066808676.1
• Coordinates: 173613..173843 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AKL17_RS00790	168805..169695	+	891	WP_174549679.1	cell division protein FtsX	-
AKL17_RS00795	169692..170423	+	732	WP_166506962.1	1-acyl-sn-glycerol-3-phosphate acyltransferase	-
AKL17_RS24765	170780..170888	+	109	Protein_165	IS5/IS1182 family transposase	-
AKL17_RS00800	170950..171879	-	930	WP_084739401.1	LysR family transcriptional regulator	-
AKL17_RS00805	171986..172846	+	861	WP_066808672.1	alpha/beta hydrolase	-
AKL17_RS24770	173151..173306	+	156	WP_166506963.1	hypothetical protein	-
AKL17_RS00810	173314..173616	-	303	WP_066808674.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AKL17_RS00815	173613..173843	-	231	WP_066808676.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
AKL17_RS00820	174158..174478	-	321	WP_066808678.1	quaternary ammonium compound efflux SMR transporter SugE	-
AKL17_RS00825	174478..175437	-	960	WP_066808681.1	acetyl-CoA carboxylase carboxyltransferase subunit alpha	-
AKL17_RS00830	175777..176813	+	1037	Protein_173	GTPase domain-containing protein	-
AKL17_RS25640	176800..178359	+	1560	WP_066808684.1	50S ribosome-binding GTPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Antitoxin ParD (6-74)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11097.85 Da
• Isoelectric Point: 5.8767

>T56906 WP_066808674.1 NZ_CP012661:c173616-173314 [Defluviimonas alba]
MTPVPIRLTPRARQDLEAIWTHGAAEWGAARADAYLIALSHLFDLIVEFPEMSPLRPEFTPPVRLHPHGAHLVVHLEDDL
GVLIVRVIGNRQDLLAALDG

Nucleotide

• Length: 303 bp

>T56906 NZ_CP012661:c173616-173314 [Defluviimonas alba]
CTGACGCCCGTGCCCATCCGCCTGACACCGCGCGCAAGGCAGGATCTGGAAGCAATCTGGACCCACGGCGCCGCCGAGTG
GGGAGCGGCGCGCGCCGATGCCTACCTGATTGCACTGTCGCATCTGTTTGATCTGATTGTCGAGTTTCCCGAAATGTCAC
CGCTGCGCCCGGAGTTCACGCCGCCCGTCCGCCTGCATCCGCATGGCGCGCATCTGGTCGTGCATCTTGAGGATGACTTG
GGGGTGCTGATCGTGCGGGTGATCGGGAACCGGCAGGATCTGCTGGCGGCGCTGGACGGATAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8612.63 Da
• Isoelectric Point: 4.7063

>AT56906 WP_066808676.1 NZ_CP012661:c173843-173613 [Defluviimonas alba]
MSTMNISLPEQMKTWVETRAEQGPFANSSDYIRELIRRDQARQQAITTLQTALDEGLNSGPAEVFDPEAFLRARRG

Nucleotide

• Length: 231 bp

>AT56906 NZ_CP012661:c173843-173613 [Defluviimonas alba]
ATGTCCACCATGAACATCTCGCTGCCCGAACAGATGAAAACCTGGGTCGAGACCCGGGCTGAACAGGGACCCTTCGCCAA
TTCCAGCGACTATATCCGCGAGCTGATCCGGCGCGATCAGGCGCGCCAGCAGGCCATCACCACTCTGCAGACGGCACTCG
ACGAAGGGCTGAACAGCGGCCCCGCCGAGGTTTTCGATCCCGAGGCCTTCTTGCGGGCCCGGCGGGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A159YYF8