Detailed information of TA system TA056869

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4090610..4091430
• Replicon: chromosome
• Accession: NZ_CP012633
• Organism: Escherichia coli strain SF-166

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: AN204_RS20130
• Protein ID: WP_001054379.1
• Coordinates: 4090610..4090867 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: AN204_RS20135
• Protein ID: WP_000123957.1
• Coordinates: 4090879..4091430 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AN204_RS20110	4085897..4087003	+	1107	WP_001332032.1	N-acetylneuraminate epimerase	-
AN204_RS20115	4087067..4088047	+	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
AN204_RS20120	4088630..4089856	-	1227	Protein_3834	helicase YjhR	-
AN204_RS20125	4089934..4090233	+	300	WP_001332034.1	GNAT family N-acetyltransferase	-
AN204_RS20130	4090610..4090867	+	258	WP_001054379.1	YjhX family toxin	Toxin
AN204_RS20135	4090879..4091430	+	552	WP_000123957.1	N-acetyltransferase	Antitoxin
AN204_RS20140	4091482..4092228	+	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
AN204_RS20145	4092356..4092616	+	261	WP_000077645.1	hypothetical protein	-
AN204_RS28240	4092654..4092770	+	117	Protein_3840	VOC family protein	-
AN204_RS20150	4093015..4094136	+	1122	WP_000010833.1	M42 family metallopeptidase	-
AN204_RS20155	4094133..4094411	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
AN204_RS20160	4094423..4095736	+	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB	4083105..4099651	16546

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T56869 WP_001054379.1 NZ_CP012633:4090610-4090867 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T56869 NZ_CP012633:4090610-4090867 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT56869 WP_000123957.1 NZ_CP012633:4090879-4091430 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT56869 NZ_CP012633:4090879-4091430 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030