Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4269860..4270695 Replicon chromosome
Accession NZ_CP012631
Organism Escherichia coli strain SF-173

Toxin (Protein)


Gene name yeeV Uniprot ID Q1R2L4
Locus tag AN205_RS21265 Protein ID WP_001094426.1
Coordinates 4269860..4270237 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID Q1R2L5
Locus tag AN205_RS21270 Protein ID WP_001285575.1
Coordinates 4270327..4270695 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN205_RS21245 4265363..4265542 + 180 WP_001298063.1 hypothetical protein -
AN205_RS21250 4265941..4267917 - 1977 WP_000464678.1 hypothetical protein -
AN205_RS21255 4269166..4269363 - 198 WP_000839272.1 DUF957 domain-containing protein -
AN205_RS21260 4269375..4269863 - 489 WP_000761683.1 hypothetical protein -
AN205_RS21265 4269860..4270237 - 378 WP_001094426.1 TA system toxin CbtA family protein Toxin
AN205_RS21270 4270327..4270695 - 369 WP_001285575.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AN205_RS21275 4270775..4270996 - 222 WP_000692350.1 DUF987 domain-containing protein -
AN205_RS21280 4271083..4271559 - 477 WP_001298074.1 RadC family protein -
AN205_RS21285 4271574..4272059 - 486 WP_000213697.1 antirestriction protein -
AN205_RS21290 4272150..4272968 - 819 WP_001175160.1 DUF945 domain-containing protein -
AN205_RS21295 4273058..4273291 - 234 WP_001278290.1 DUF905 family protein -
AN205_RS21300 4273297..4273974 - 678 WP_001097301.1 hypothetical protein -
AN205_RS21305 4274122..4274802 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4259279..4284569 25290


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14072.99 Da        Isoelectric Point: 7.3523

>T56839 WP_001094426.1 NZ_CP012631:c4270237-4269860 [Escherichia coli]
MNTLPDTHIREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T56839 NZ_CP012631:c4270237-4269860 [Escherichia coli]
ATGAACACATTACCCGATACACACATACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13709.52 Da        Isoelectric Point: 6.6258

>AT56839 WP_001285575.1 NZ_CP012631:c4270695-4270327 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT56839 NZ_CP012631:c4270695-4270327 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A454ABD6


Antitoxin

Source ID Structure
AlphaFold DB A0A454ABF5

References