Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3661976..3662594 Replicon chromosome
Accession NZ_CP012631
Organism Escherichia coli strain SF-173

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag AN205_RS18370 Protein ID WP_001291435.1
Coordinates 3662376..3662594 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag AN205_RS18365 Protein ID WP_000344800.1
Coordinates 3661976..3662350 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN205_RS18355 3657066..3658259 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
AN205_RS18360 3658282..3661431 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
AN205_RS18365 3661976..3662350 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
AN205_RS18370 3662376..3662594 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
AN205_RS18375 3662768..3663319 + 552 WP_000102543.1 maltose O-acetyltransferase -
AN205_RS18380 3663435..3663905 + 471 WP_000136192.1 YlaC family protein -
AN205_RS18385 3664069..3665619 + 1551 WP_001350616.1 cyclic-guanylate-specific phosphodiesterase PdeB -
AN205_RS18390 3665661..3666014 - 354 WP_000878140.1 DUF1428 domain-containing protein -
AN205_RS18395 3666393..3666704 + 312 WP_000409908.1 MGMT family protein -
AN205_RS18400 3666735..3667307 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T56834 WP_001291435.1 NZ_CP012631:3662376-3662594 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T56834 NZ_CP012631:3662376-3662594 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT56834 WP_000344800.1 NZ_CP012631:3661976-3662350 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT56834 NZ_CP012631:3661976-3662350 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References