Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1890302..1891133 Replicon chromosome
Accession NZ_CP012631
Organism Escherichia coli strain SF-173

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag AN205_RS09275 Protein ID WP_000854814.1
Coordinates 1890302..1890676 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag AN205_RS09280 Protein ID WP_001285586.1
Coordinates 1890765..1891133 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN205_RS09240 1885699..1886864 + 1166 Protein_1776 serine-type D-Ala-D-Ala carboxypeptidase DacD -
AN205_RS09245 1886983..1887456 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
AN205_RS09250 1887654..1888712 + 1059 WP_001200890.1 FUSC family protein -
AN205_RS09255 1888884..1889213 + 330 WP_000450409.1 DUF496 family protein -
AN205_RS09260 1889314..1889496 - 183 WP_001016348.1 hypothetical protein -
AN205_RS26270 1889550..1889696 + 147 Protein_1781 transposase domain-containing protein -
AN205_RS28890 1889985..1890098 - 114 WP_001161660.1 DUF957 domain-containing protein -
AN205_RS09270 1890111..1890305 - 195 WP_000988601.1 hypothetical protein -
AN205_RS09275 1890302..1890676 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
AN205_RS09280 1890765..1891133 - 369 WP_001285586.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
AN205_RS09285 1891207..1891428 - 222 WP_000692323.1 DUF987 domain-containing protein -
AN205_RS09290 1891497..1891973 - 477 WP_001298074.1 RadC family protein -
AN205_RS09295 1891988..1892461 - 474 WP_000855071.1 antirestriction protein -
AN205_RS09300 1892724..1893545 - 822 WP_001234570.1 DUF945 domain-containing protein -
AN205_RS09305 1893766..1894176 - 411 WP_000846704.1 hypothetical protein -
AN205_RS09310 1894192..1894869 - 678 WP_001362823.1 hypothetical protein -
AN205_RS09315 1895005..1896075 - 1071 WP_000102631.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T56821 WP_000854814.1 NZ_CP012631:c1890676-1890302 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T56821 NZ_CP012631:c1890676-1890302 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT56821 WP_001285586.1 NZ_CP012631:c1891133-1890765 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT56821 NZ_CP012631:c1891133-1890765 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References