Detailed information of TA system TA056810

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 4356055..4356869
• Replicon: chromosome
• Accession: NZ_CP012625
• Organism: Escherichia coli strain SF-468

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: AN206_RS22150
• Protein ID: WP_001054376.1
• Coordinates: 4356055..4356312 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: A0A8E0IVE5
• Locus tag: AN206_RS22155
• Protein ID: WP_001350781.1
• Coordinates: 4356324..4356869 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AN206_RS22125	4351343..4352449	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
AN206_RS22130	4352514..4353494	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
AN206_RS22135	4354077..4355317	-	1241	Protein_4247	helicase YjhR	-
AN206_RS30585	4355433..4355678	+	246	Protein_4248	GNAT family N-acetyltransferase	-
AN206_RS22150	4356055..4356312	+	258	WP_001054376.1	hypothetical protein	Toxin
AN206_RS22155	4356324..4356869	+	546	WP_001350781.1	N-acetyltransferase	Antitoxin
AN206_RS22160	4356925..4357671	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
AN206_RS29915	4357840..4358058	+	219	Protein_4252	hypothetical protein	-
AN206_RS31035	4358096..4358212	+	117	Protein_4253	VOC family protein	-
AN206_RS22165	4358457..4359578	+	1122	WP_000010832.1	M42 family metallopeptidase	-
AN206_RS22170	4359575..4359853	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
AN206_RS22175	4359865..4361178	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimI / fimA / fimE / fimB	4345840..4365093	19253

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T56810 WP_001054376.1 NZ_CP012625:4356055-4356312 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T56810 NZ_CP012625:4356055-4356312 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19974.91 Da
• Isoelectric Point: 6.3277

>AT56810 WP_001350781.1 NZ_CP012625:4356324-4356869 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAFIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT56810 NZ_CP012625:4356324-4356869 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCGGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCTTTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82