Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4199854..4200212 Replicon chromosome
Accession NZ_CP012625
Organism Escherichia coli strain SF-468

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag AN206_RS31030 Protein ID WP_001332330.1
Coordinates 4199854..4199976 (-) Length 41 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag AN206_RS21340 Protein ID WP_000125566.1
Coordinates 4199979..4200212 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN206_RS21310 4195336..4196622 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
AN206_RS21315 4196622..4197611 + 990 WP_060710357.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
AN206_RS21320 4197608..4198429 + 822 WP_001065359.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
AN206_RS21325 4198432..4198809 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
AN206_RS21330 4198816..4199664 + 849 WP_000257201.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
AN206_RS31025 4199661..4199813 - 153 WP_146692624.1 CcdB family protein -
AN206_RS31030 4199854..4199976 - 123 WP_001332330.1 CcdB family protein Toxin
AN206_RS21340 4199979..4200212 - 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
AN206_RS21345 4200298..4200777 - 480 WP_000624375.1 type 3 dihydrofolate reductase -
AN206_RS21350 4200969..4202831 - 1863 WP_000377122.1 glutathione-regulated potassium-efflux system protein KefC -
AN206_RS21355 4202824..4203354 - 531 WP_000600749.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
AN206_RS21360 4203462..4204793 - 1332 WP_001183207.1 MFS transporter -
AN206_RS21365 4204852..4205139 - 288 WP_000203741.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-39)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 41 a.a.        Molecular weight: 4563.34 Da        Isoelectric Point: 10.9266

>T56807 WP_001332330.1 NZ_CP012625:c4199976-4199854 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIVGEINRRIVIPLTPI

Download         Length: 123 bp

>T56807 NZ_CP012625:c4199976-4199854 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTGTTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT56807 WP_000125566.1 NZ_CP012625:c4200212-4199979 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT56807 NZ_CP012625:c4200212-4199979 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References