Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2066330..2067161 Replicon chromosome
Accession NZ_CP012625
Organism Escherichia coli strain SF-468

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag AN206_RS10390 Protein ID WP_000854815.1
Coordinates 2066330..2066704 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag AN206_RS10395 Protein ID WP_001280918.1
Coordinates 2066793..2067161 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN206_RS10355 2061726..2062892 + 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
AN206_RS10360 2063011..2063484 + 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
AN206_RS10365 2063682..2064740 + 1059 WP_001200889.1 FUSC family protein -
AN206_RS10370 2064912..2065241 + 330 WP_000450409.1 DUF496 family protein -
AN206_RS10375 2065342..2065524 - 183 WP_001296208.1 hypothetical protein -
AN206_RS27915 2065578..2065724 + 147 Protein_1994 transposase domain-containing protein -
AN206_RS30845 2066013..2066126 - 114 WP_001161660.1 DUF957 domain-containing protein -
AN206_RS10385 2066139..2066333 - 195 WP_000988600.1 hypothetical protein -
AN206_RS10390 2066330..2066704 - 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
AN206_RS10395 2066793..2067161 - 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AN206_RS10400 2067177..2067821 - 645 WP_021524743.1 hypothetical protein -
AN206_RS10405 2067840..2068061 - 222 WP_000692345.1 DUF987 domain-containing protein -
AN206_RS10410 2068124..2068600 - 477 WP_001186200.1 RadC family protein -
AN206_RS10415 2068616..2069089 - 474 WP_001542276.1 antirestriction protein -
AN206_RS10420 2069183..2069428 - 246 WP_001164966.1 hypothetical protein -
AN206_RS10425 2069428..2070246 - 819 WP_001542275.1 DUF945 domain-containing protein -
AN206_RS10430 2070467..2070877 - 411 WP_000846703.1 hypothetical protein -
AN206_RS10435 2070893..2071570 - 678 WP_001362823.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T56793 WP_000854815.1 NZ_CP012625:c2066704-2066330 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T56793 NZ_CP012625:c2066704-2066330 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT56793 WP_001280918.1 NZ_CP012625:c2067161-2066793 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT56793 NZ_CP012625:c2067161-2066793 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References