Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2564352..2565022 Replicon chromosome
Accession NZ_CP012621
Organism Zobellella denitrificans strain F13-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AN401_RS12235 Protein ID WP_096779513.1
Coordinates 2564352..2564771 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AN401_RS12240 Protein ID WP_096779514.1
Coordinates 2564768..2565022 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN401_RS12205 2560401..2560970 - 570 WP_096779508.1 recombinase family protein -
AN401_RS12210 2561150..2561377 - 228 WP_096779509.1 type I toxin-antitoxin system ptaRNA1 family toxin -
AN401_RS12215 2561443..2561697 - 255 WP_096779510.1 hypothetical protein -
AN401_RS12220 2561700..2563100 - 1401 WP_096780364.1 P-type conjugative transfer protein TrbL -
AN401_RS12225 2563115..2563345 - 231 WP_096779511.1 entry exclusion lipoprotein TrbK -
AN401_RS12230 2563357..2564127 - 771 WP_096779512.1 P-type conjugative transfer protein TrbJ -
AN401_RS12235 2564352..2564771 - 420 WP_096779513.1 type II toxin-antitoxin system VapC family toxin Toxin
AN401_RS12240 2564768..2565022 - 255 WP_096779514.1 Arc family DNA-binding protein Antitoxin
AN401_RS12245 2565088..2566866 - 1779 WP_096779515.1 relaxase/mobilization nuclease domain-containing protein -
AN401_RS12250 2566863..2567237 - 375 WP_096779516.1 conjugal transfer transcriptional regulator TraJ -
AN401_RS12255 2568105..2568860 - 756 WP_096779517.1 ABC transporter ATPase -
AN401_RS12260 2568847..2569698 - 852 WP_096779518.1 helicase RepA family protein -
AN401_RS12265 2569703..2569933 - 231 WP_096779519.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(5-45)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14732.97 Da        Isoelectric Point: 4.4189

>T56787 WP_096779513.1 NZ_CP012621:c2564771-2564352 [Zobellella denitrificans]
MIVLDTNVVSEPLRQAPEARVIEWIDAQALETLYLSAITVAELRFGMASLPAGKRRDGLQESLEKQILPLFAGRVLPFDM
SASKAYAELMAKARAAGLAIGAADGYIAATAAANGMIVATRDVSPFEAAGVDTINPWEA

Download         Length: 420 bp

>T56787 NZ_CP012621:c2564771-2564352 [Zobellella denitrificans]
ATGATCGTACTGGATACCAATGTCGTTTCGGAGCCACTGCGTCAGGCCCCCGAAGCCCGGGTGATTGAATGGATTGACGC
GCAGGCGCTCGAAACGCTTTACCTGTCGGCAATCACGGTGGCCGAACTGCGTTTCGGGATGGCATCGTTGCCTGCCGGCA
AACGCCGTGACGGGTTGCAAGAGAGCCTGGAAAAGCAAATTCTGCCGCTGTTTGCCGGGCGGGTGCTGCCGTTCGATATG
TCGGCATCGAAAGCCTACGCCGAGCTGATGGCGAAGGCACGGGCAGCCGGCCTGGCAATCGGCGCAGCCGACGGATATAT
CGCCGCGACGGCCGCCGCCAATGGCATGATCGTCGCCACGCGAGACGTCAGCCCGTTTGAAGCGGCGGGCGTAGACACTA
TTAACCCTTGGGAAGCCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9383.89 Da        Isoelectric Point: 10.4826

>AT56787 WP_096779514.1 NZ_CP012621:c2565022-2564768 [Zobellella denitrificans]
MPSITVRNVPDEVHRALKVLAAQHGRSAEAEIRDILENAVKPKGRKKLGSLLAEIGRRAKLTDEDLKTIEQVRDKTPAKP
MTFE

Download         Length: 255 bp

>AT56787 NZ_CP012621:c2565022-2564768 [Zobellella denitrificans]
ATGCCGTCTATCACTGTTAGAAATGTGCCGGATGAGGTGCATCGTGCCCTGAAGGTGCTGGCTGCTCAGCATGGGCGCAG
CGCCGAAGCGGAAATCCGCGACATCCTGGAAAATGCCGTAAAGCCGAAAGGCCGGAAGAAACTGGGTTCTCTGCTGGCCG
AAATCGGCCGTCGGGCCAAGTTGACCGATGAAGATCTTAAAACCATCGAGCAGGTGCGCGACAAGACCCCTGCCAAGCCG
ATGACGTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References