Detailed information of TA system TA056786

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2546759..2547429
• Replicon: chromosome
• Accession: NZ_CP012621
• Organism: Zobellella denitrificans strain F13-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AN401_RS12165
• Protein ID: WP_096779503.1
• Coordinates: 2546759..2547178 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: AN401_RS12170
• Protein ID: WP_096779514.1
• Coordinates: 2547175..2547429 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AN401_RS12140	2542873..2543145	+	273	WP_094038675.1	2Fe-2S ferredoxin-like protein	-
AN401_RS12145	2543142..2543405	-	264	WP_094038676.1	DUF1496 domain-containing protein	-
AN401_RS12150	2543477..2545825	+	2349	WP_096779500.1	fatty acid cis/trans isomerase	-
AN401_RS12155	2545956..2546354	-	399	WP_096779501.1	HI0074 family nucleotidyltransferase substrate-binding subunit	-
AN401_RS12160	2546344..2546634	-	291	WP_096779502.1	nucleotidyltransferase domain-containing protein	-
AN401_RS12165	2546759..2547178	-	420	WP_096779503.1	type II toxin-antitoxin system VapC family toxin	Toxin
AN401_RS12170	2547175..2547429	-	255	WP_096779514.1	Arc family DNA-binding protein	Antitoxin
AN401_RS12175	2547764..2551582	-	3819	WP_096779504.1	SIR2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

• Arc-like DNA binding domain (5-45)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14806.02 Da
• Isoelectric Point: 4.4076

>T56786 WP_096779503.1 NZ_CP012621:c2547178-2546759 [Zobellella denitrificans]
MIVLDTNVVSEPLRQAPEAQVIDWIDAQALETLYLSAITVAELRFGMASLPAGKRRDRLQESLEKQILPLFAGRVLPFDM
SASKAYGELMAKARTAGLAIGAADGYIAATAAANGMIVATRDVSPFEAAGVDTINPWEA

Nucleotide

• Length: 420 bp

>T56786 NZ_CP012621:c2547178-2546759 [Zobellella denitrificans]
ATGATCGTACTGGATACCAATGTCGTTTCGGAGCCACTGCGTCAGGCCCCCGAAGCCCAGGTGATTGACTGGATTGACGC
GCAGGCGCTCGAAACGCTTTACCTGTCGGCTATCACGGTGGCCGAACTGCGTTTCGGGATGGCGTCGTTGCCTGCCGGCA
AACGCCGTGACCGGTTGCAAGAGAGCCTGGAAAAGCAAATTCTGCCGCTGTTTGCCGGGCGGGTGCTGCCGTTCGATATG
TCGGCATCGAAAGCCTATGGCGAACTGATGGCGAAGGCACGGACAGCCGGACTGGCAATCGGCGCAGCCGATGGTTATAT
CGCAGCGACGGCCGCCGCCAATGGCATGATCGTCGCCACGCGAGACGTCAGCCCGTTCGAAGCGGCGGGCGTAGACACCA
TTAACCCTTGGGAAGCCTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9383.89 Da
• Isoelectric Point: 10.4826

>AT56786 WP_096779514.1 NZ_CP012621:c2547429-2547175 [Zobellella denitrificans]
MPSITVRNVPDEVHRALKVLAAQHGRSAEAEIRDILENAVKPKGRKKLGSLLAEIGRRAKLTDEDLKTIEQVRDKTPAKP
MTFE

Nucleotide

• Length: 255 bp

>AT56786 NZ_CP012621:c2547429-2547175 [Zobellella denitrificans]
ATGCCGTCTATCACTGTTAGAAATGTGCCGGATGAGGTGCATCGTGCCCTGAAGGTGCTGGCTGCCCAGCACGGGCGCAG
CGCCGAAGCGGAAATCCGCGACATCCTGGAAAATGCCGTAAAGCCGAAAGGCCGGAAGAAACTGGGTTCTCTGCTGGCCG
AGATTGGCCGACGGGCCAAGTTGACCGATGAAGATCTTAAAACCATCGAGCAGGTGCGCGACAAGACCCCTGCCAAGCCC
ATGACGTTCGAATGA