Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 754908..756650 Replicon chromosome
Accession NZ_CP012606
Organism Ralstonia insidiosa strain FC1138

Toxin (Protein)


Gene name doc Uniprot ID S9T903
Locus tag ACS15_RS21910 Protein ID WP_021193939.1
Coordinates 755748..756650 (-) Length 301 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID S9RYF6
Locus tag ACS15_RS21905 Protein ID WP_021193940.1
Coordinates 754908..755735 (-) Length 276 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACS15_RS21885 750033..751529 - 1497 WP_021193944.1 aldehyde dehydrogenase -
ACS15_RS21890 751546..752349 - 804 WP_021193943.1 aspartate dehydrogenase -
ACS15_RS21895 752382..754109 - 1728 WP_031329076.1 thiamine pyrophosphate-binding protein -
ACS15_RS21900 754102..754905 - 804 WP_031329074.1 SDR family oxidoreductase -
ACS15_RS21905 754908..755735 - 828 WP_021193940.1 IclR family transcriptional regulator Antitoxin
ACS15_RS21910 755748..756650 - 903 WP_021193939.1 alpha/beta hydrolase Toxin
ACS15_RS21915 756655..757191 - 537 WP_021193938.1 cupin domain-containing protein -
ACS15_RS21920 757237..758010 - 774 WP_021193937.1 SDR family oxidoreductase -
ACS15_RS21925 758003..759070 - 1068 WP_021193936.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
ACS15_RS21930 759142..759447 - 306 WP_021193935.1 hypothetical protein -
ACS15_RS21935 759906..761444 + 1539 WP_021193934.1 cache domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-288)

Antitoxin

Transcription regulator IclR, N-terminal

(19-68)


Sequences

Toxin        


Download         Length: 301 a.a.        Molecular weight: 32115.56 Da        Isoelectric Point: 6.6900

>T56780 WP_021193939.1 NZ_CP012606:c756650-755748 [Ralstonia insidiosa]
MSTQAVMSSHPFRVADALAVLGAEFAEHTVAINEQGDRIGFRQWGERGPVVVLLHGISSSAASWLPCAQVLSQTMRVFAW
DAPGYGNSTPLQTLAPCAADYAVRLRAWLAALHVKPDVIVGHSLGALMASAYVAEAPAAMQVRNLLLLNPAQGYGQPGRE
AQSRTMLAQRLATLEKLGIDGMAESRHAHLLRPDASNEERAWVRWNMKRLNDGGYRQAVAMLSGDDIGAYLRKRPASTPA
RVACGDVDGITPPQGCEALAETFDLPFALLPSAGHASYIDAPEAVAGWIEQAVLSQSRNA

Download         Length: 903 bp

>T56780 NZ_CP012606:c756650-755748 [Ralstonia insidiosa]
ATGAGCACGCAGGCTGTCATGTCCTCCCACCCGTTCCGTGTTGCTGATGCACTTGCCGTGCTCGGCGCCGAGTTTGCCGA
ACACACCGTCGCAATCAACGAGCAAGGCGATCGCATTGGCTTTCGGCAATGGGGTGAGCGCGGGCCGGTGGTGGTGCTGT
TGCACGGCATCAGTTCCAGCGCCGCGTCATGGCTGCCTTGCGCGCAAGTCCTTTCGCAAACCATGCGCGTGTTCGCGTGG
GATGCGCCGGGCTACGGCAACTCCACGCCGCTGCAAACGCTGGCTCCCTGCGCTGCTGACTATGCAGTGCGCCTGCGCGC
TTGGCTGGCCGCTCTGCATGTGAAGCCGGATGTGATTGTTGGGCATTCGCTGGGCGCGCTGATGGCGTCTGCCTATGTGG
CCGAAGCGCCGGCGGCGATGCAAGTGCGCAACTTGCTGCTGCTGAACCCCGCACAGGGCTACGGCCAACCAGGGAGGGAG
GCGCAGTCGCGCACCATGCTGGCGCAGCGTCTGGCAACGCTCGAAAAGCTTGGCATCGACGGCATGGCGGAATCGCGCCA
CGCGCATTTGCTTCGACCCGATGCGAGCAACGAAGAGCGCGCCTGGGTGCGCTGGAACATGAAGCGCCTGAACGATGGGG
GCTACCGCCAGGCGGTGGCCATGCTCAGCGGCGACGACATTGGCGCCTATCTGCGCAAGCGCCCGGCATCGACACCCGCC
CGCGTGGCCTGTGGCGATGTTGACGGCATCACGCCGCCGCAAGGCTGCGAAGCCTTGGCCGAGACGTTCGATCTGCCGTT
CGCGCTCTTACCGTCTGCCGGACACGCTTCCTATATCGATGCACCTGAAGCGGTTGCAGGCTGGATCGAACAAGCCGTCC
TCTCTCAATCCCGAAACGCGTAA

Antitoxin


Download         Length: 276 a.a.        Molecular weight: 30690.43 Da        Isoelectric Point: 6.1475

>AT56780 WP_021193940.1 NZ_CP012606:c755735-754908 [Ralstonia insidiosa]
MSNDLISEDVQEKYIVPGLERGLRLLCEFSHKDRVLSAPELARRLKVPRSTVFRLLTTLEVMGFVERVDGGRDFRLGMAV
LRLGFEYLASLELTELGRPLLDRLRDEIHYPCNLVVRDGRSIVYVAKSVAPTPFTSSVNVGTRLPAHATVLGRVLLADLS
LAELRQLYPEPQLEVFSANTPRTVEELFEMVQRDRDHGYVLQEGFFEANISTIAAPVLDRGGKVVAALGTTIPSPRIEPA
QLDTMIDKVRAAAGELSYLLDYRPASGKVVNLFRE

Download         Length: 828 bp

>AT56780 NZ_CP012606:c755735-754908 [Ralstonia insidiosa]
ATGAGCAACGACCTCATCTCCGAAGACGTGCAGGAAAAGTACATCGTCCCCGGGCTCGAACGCGGCCTGCGCCTGCTGTG
CGAGTTCAGCCACAAAGATCGCGTGCTGTCTGCACCGGAACTGGCGCGCCGGCTGAAGGTGCCGCGCTCGACTGTGTTCC
GTTTGCTCACCACGCTCGAAGTCATGGGCTTTGTGGAGCGTGTCGACGGTGGCCGTGATTTCCGCCTCGGCATGGCGGTG
CTGCGCCTGGGCTTTGAATACCTTGCCTCGCTGGAGCTGACCGAGCTGGGCCGTCCGCTGCTCGATCGCCTGCGCGATGA
AATCCACTACCCGTGCAACCTCGTGGTGCGCGATGGCCGCTCGATCGTCTATGTGGCGAAATCGGTGGCGCCCACGCCGT
TCACGAGCTCCGTCAATGTCGGCACGCGCCTGCCTGCGCATGCCACCGTGCTGGGCCGCGTGCTGCTGGCGGATCTGTCA
CTGGCTGAGTTGCGCCAGCTCTATCCAGAGCCGCAGCTGGAAGTGTTTTCTGCCAACACGCCGCGCACGGTGGAAGAGCT
GTTCGAGATGGTCCAGCGCGACCGTGACCACGGCTACGTACTGCAAGAGGGCTTCTTCGAAGCCAACATCTCCACAATCG
CCGCACCCGTGCTGGACCGCGGCGGCAAGGTGGTCGCCGCGCTCGGCACGACGATCCCGTCGCCGCGCATCGAGCCCGCC
CAACTGGACACGATGATCGACAAGGTGCGCGCCGCCGCCGGTGAGTTGTCGTACCTGCTGGACTATCGCCCCGCCAGCGG
CAAGGTCGTCAACCTGTTCCGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A100HQ42

Antitoxin

Source ID Structure
AlphaFold DB A0A100HS72

References