Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2514635..2515158 Replicon chromosome
Accession NZ_CP012593
Organism Staphylococcus aureus strain HOU1444-VR

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag IT770_RS12595 Protein ID WP_000074049.1
Coordinates 2514635..2514901 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag IT770_RS12600 Protein ID WP_000587616.1
Coordinates 2514901..2515158 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT770_RS12575 2509942..2511129 - 1188 WP_000026189.1 MFS transporter -
IT770_RS12580 2511525..2512301 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
IT770_RS12585 2512294..2512956 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
IT770_RS12590 2513204..2514280 - 1077 WP_001076673.1 M42 family metallopeptidase -
IT770_RS12595 2514635..2514901 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
IT770_RS12600 2514901..2515158 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IT770_RS12605 2515517..2515972 + 456 WP_000732076.1 DUF1307 domain-containing protein -
IT770_RS12610 2516140..2517717 - 1578 WP_054575613.1 FMN-binding glutamate synthase family protein -
IT770_RS12615 2517912..2518661 + 750 WP_000072461.1 CPBP family intramembrane metalloprotease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T56777 WP_000074049.1 NZ_CP012593:c2514901-2514635 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T56777 NZ_CP012593:c2514901-2514635 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT56777 WP_000587616.1 NZ_CP012593:c2515158-2514901 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT56777 NZ_CP012593:c2515158-2514901 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References