Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2140975..2141489 Replicon chromosome
Accession NZ_CP012593
Organism Staphylococcus aureus strain HOU1444-VR

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IT770_RS10655 Protein ID WP_000581792.1
Coordinates 2140975..2141184 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IT770_RS10660 Protein ID WP_000138932.1
Coordinates 2141196..2141489 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT770_RS10635 2136483..2137841 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
IT770_RS10640 2137856..2138926 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IT770_RS10645 2139244..2140446 + 1203 WP_001109939.1 rod shape-determining protein RodA -
IT770_RS10650 2140710..2140847 - 138 WP_000828354.1 hypothetical protein -
IT770_RS10655 2140975..2141184 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
IT770_RS10660 2141196..2141489 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IT770_RS10665 2141655..2143139 + 1485 WP_000571549.1 cardiolipin synthase -
IT770_RS10670 2143167..2143814 + 648 WP_001187630.1 HD domain-containing protein -
IT770_RS10675 2144727..2145599 - 873 WP_000725802.1 membrane protein insertase YidC -
IT770_RS10680 2145685..2146326 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T56771 WP_000581792.1 NZ_CP012593:c2141184-2140975 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T56771 NZ_CP012593:c2141184-2140975 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT56771 WP_000138932.1 NZ_CP012593:c2141489-2141196 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT56771 NZ_CP012593:c2141489-2141196 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References