Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2067560..2068095 Replicon chromosome
Accession NZ_CP012593
Organism Staphylococcus aureus strain HOU1444-VR

Toxin (Protein)


Gene name TscT Uniprot ID A0A4P7P340
Locus tag IT770_RS10290 Protein ID WP_001103945.1
Coordinates 2067560..2067883 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID X5IA75
Locus tag IT770_RS10295 Protein ID WP_001058492.1
Coordinates 2067886..2068095 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT770_RS10260 2062710..2063051 - 342 WP_012990920.1 hypothetical protein -
IT770_RS10265 2063591..2064232 - 642 WP_054575621.1 pathogenicity island protein -
IT770_RS10270 2064234..2064497 - 264 WP_001804819.1 hypothetical protein -
IT770_RS10275 2064499..2064861 - 363 WP_054575622.1 hypothetical protein -
IT770_RS10280 2065140..2066609 - 1470 WP_053040304.1 virulence-associated E family protein -
IT770_RS10285 2066626..2067495 - 870 WP_031765319.1 primase alpha helix C-terminal domain-containing protein -
IT770_RS10290 2067560..2067883 - 324 WP_001103945.1 DUF1474 family protein Toxin
IT770_RS10295 2067886..2068095 - 210 WP_001058492.1 hypothetical protein Antitoxin
IT770_RS10300 2068088..2068234 - 147 WP_000708434.1 hypothetical protein -
IT770_RS10305 2068231..2068548 - 318 WP_000481967.1 helix-turn-helix domain-containing protein -
IT770_RS10310 2068553..2068771 - 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
IT770_RS10315 2068944..2069618 + 675 WP_054575668.1 helix-turn-helix transcriptional regulator -
IT770_RS10320 2069632..2070804 + 1173 WP_000179346.1 site-specific integrase -
IT770_RS10325 2070873..2072489 - 1617 WP_000240642.1 chaperonin GroEL -
IT770_RS10330 2072565..2072849 - 285 WP_054575667.1 co-chaperone GroES -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - map / hlb / scn / chp / sak / see / hlb / groEL / hld 1955906..2090779 134873


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12665.26 Da        Isoelectric Point: 4.7124

>T56769 WP_001103945.1 NZ_CP012593:c2067883-2067560 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDAKNSIKVAE

Download         Length: 324 bp

>T56769 NZ_CP012593:c2067883-2067560 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTTTATTTAAAAGAGTTCGATGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGA
GTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8238.28 Da        Isoelectric Point: 4.3718

>AT56769 WP_001058492.1 NZ_CP012593:c2068095-2067886 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT56769 NZ_CP012593:c2068095-2067886 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTAGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7P340

Antitoxin

Source ID Structure
AlphaFold DB X5IA75

References