Detailed information of TA system TA056769

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2067560..2068095
• Replicon: chromosome
• Accession: NZ_CP012593
• Organism: Staphylococcus aureus strain HOU1444-VR

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: A0A4P7P340
• Locus tag: IT770_RS10290
• Protein ID: WP_001103945.1
• Coordinates: 2067560..2067883 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IA75
• Locus tag: IT770_RS10295
• Protein ID: WP_001058492.1
• Coordinates: 2067886..2068095 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IT770_RS10260	2062710..2063051	-	342	WP_012990920.1	hypothetical protein	-
IT770_RS10265	2063591..2064232	-	642	WP_054575621.1	pathogenicity island protein	-
IT770_RS10270	2064234..2064497	-	264	WP_001804819.1	hypothetical protein	-
IT770_RS10275	2064499..2064861	-	363	WP_054575622.1	hypothetical protein	-
IT770_RS10280	2065140..2066609	-	1470	WP_053040304.1	virulence-associated E family protein	-
IT770_RS10285	2066626..2067495	-	870	WP_031765319.1	primase alpha helix C-terminal domain-containing protein	-
IT770_RS10290	2067560..2067883	-	324	WP_001103945.1	DUF1474 family protein	Toxin
IT770_RS10295	2067886..2068095	-	210	WP_001058492.1	hypothetical protein	Antitoxin
IT770_RS10300	2068088..2068234	-	147	WP_000708434.1	hypothetical protein	-
IT770_RS10305	2068231..2068548	-	318	WP_000481967.1	helix-turn-helix domain-containing protein	-
IT770_RS10310	2068553..2068771	-	219	WP_000153640.1	helix-turn-helix transcriptional regulator	-
IT770_RS10315	2068944..2069618	+	675	WP_054575668.1	helix-turn-helix transcriptional regulator	-
IT770_RS10320	2069632..2070804	+	1173	WP_000179346.1	site-specific integrase	-
IT770_RS10325	2070873..2072489	-	1617	WP_000240642.1	chaperonin GroEL	-
IT770_RS10330	2072565..2072849	-	285	WP_054575667.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / see / hlb / groEL / hld	1955906..2090779	134873

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12665.26 Da
• Isoelectric Point: 4.7124

>T56769 WP_001103945.1 NZ_CP012593:c2067883-2067560 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDAKNSIKVAE

Nucleotide

• Length: 324 bp

>T56769 NZ_CP012593:c2067883-2067560 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTTTATTTAAAAGAGTTCGATGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGA
GTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8238.28 Da
• Isoelectric Point: 4.3718

>AT56769 WP_001058492.1 NZ_CP012593:c2068095-2067886 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT56769 NZ_CP012593:c2068095-2067886 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTAGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: A0A4P7P340

Antitoxin

• AlphaFold DB: X5IA75