Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 868439..868916 Replicon chromosome
Accession NZ_CP012593
Organism Staphylococcus aureus strain HOU1444-VR

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag IT770_RS04250 Protein ID WP_000052076.1
Coordinates 868439..868627 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag IT770_RS04255 Protein ID WP_001059690.1
Coordinates 868656..868916 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT770_RS04220 864433..864954 + 522 WP_000824482.1 hypothetical protein -
IT770_RS04225 865295..865981 + 687 WP_000141557.1 thermonuclease family protein -
IT770_RS04230 866338..866538 + 201 WP_001059082.1 cold-shock protein -
IT770_RS04235 867030..867248 - 219 WP_000005886.1 hypothetical protein -
IT770_RS04240 867310..867594 - 285 WP_001004399.1 hypothetical protein -
IT770_RS04245 867682..868251 - 570 WP_001106654.1 hypothetical protein -
IT770_RS04250 868439..868627 - 189 WP_000052076.1 hypothetical protein Toxin
IT770_RS04255 868656..868916 - 261 WP_001059690.1 hypothetical protein Antitoxin
IT770_RS04260 869257..869460 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
IT770_RS04265 869457..869693 - 237 WP_000349581.1 hypothetical protein -
IT770_RS04270 869918..870499 + 582 WP_054575602.1 phosphoglycerate mutase family protein -
IT770_RS04275 870572..871189 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
IT770_RS04280 871344..871838 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
IT770_RS04285 872237..872659 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
IT770_RS04290 872807..873523 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T56762 WP_000052076.1 NZ_CP012593:c868627-868439 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T56762 NZ_CP012593:c868627-868439 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT56762 WP_001059690.1 NZ_CP012593:c868916-868656 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT56762 NZ_CP012593:c868916-868656 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References