Detailed information of TA system TA056761

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 404973..405508
• Replicon: chromosome
• Accession: NZ_CP012593
• Organism: Staphylococcus aureus strain HOU1444-VR

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: A0A4P7P340
• Locus tag: IT770_RS01955
• Protein ID: WP_001103945.1
• Coordinates: 405185..405508 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: IT770_RS01950
• Protein ID: WP_001058486.1
• Coordinates: 404973..405182 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IT770_RS01910	400024..400527	+	504	WP_000934799.1	single-stranded DNA-binding protein	-
IT770_RS01915	400579..400821	+	243	WP_000897044.1	30S ribosomal protein S18	-
IT770_RS01920	401060..401960	-	901	Protein_381	Abi family protein	-
IT770_RS01925	401962..403176	-	1215	WP_031765313.1	site-specific integrase	-
IT770_RS01930	403440..404165	-	726	WP_000668215.1	helix-turn-helix transcriptional regulator	-
IT770_RS01935	404337..404549	+	213	WP_001245562.1	helix-turn-helix transcriptional regulator	-
IT770_RS01940	404550..404822	+	273	WP_001138300.1	helix-turn-helix domain-containing protein	-
IT770_RS01945	404834..404980	+	147	WP_000784875.1	hypothetical protein	-
IT770_RS01950	404973..405182	+	210	WP_001058486.1	hypothetical protein	Antitoxin
IT770_RS01955	405185..405508	+	324	WP_001103945.1	DUF1474 family protein	Toxin
IT770_RS01960	405573..406442	+	870	WP_031765319.1	primase alpha helix C-terminal domain-containing protein	-
IT770_RS01965	406459..407916	+	1458	WP_031765320.1	virulence-associated E family protein	-
IT770_RS01970	408217..408579	+	363	WP_031765322.1	hypothetical protein	-
IT770_RS01975	408581..408865	+	285	WP_000998179.1	hypothetical protein	-
IT770_RS01980	408862..409503	+	642	WP_031765326.1	pathogenicity island protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	tsst-1	395964..422860	26896

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12665.26 Da
• Isoelectric Point: 4.7124

>T56761 WP_001103945.1 NZ_CP012593:405185-405508 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDAKNSIKVAE

Nucleotide

• Length: 324 bp

>T56761 NZ_CP012593:405185-405508 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTTTATTTAAAAGAGTTCGATGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGA
GTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT56761 WP_001058486.1 NZ_CP012593:404973-405182 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT56761 NZ_CP012593:404973-405182 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: A0A4P7P340