Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1306443..1307025 Replicon chromosome
Accession NZ_CP012590
Organism Actinomyces sp. oral taxon 414 strain F0588

Toxin (Protein)


Gene name mazF Uniprot ID A0A0M4H4U8
Locus tag AM609_RS05290 Protein ID WP_053586438.1
Coordinates 1306443..1306790 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0M4GDV0
Locus tag AM609_RS05295 Protein ID WP_053586439.1
Coordinates 1306777..1307025 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM609_RS05285 1302827..1306408 + 3582 WP_053586437.1 proline dehydrogenase family protein -
AM609_RS05290 1306443..1306790 - 348 WP_053586438.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AM609_RS05295 1306777..1307025 - 249 WP_053586439.1 ribbon-helix-helix domain-containing protein Antitoxin
AM609_RS05300 1307163..1307915 - 753 WP_053586440.1 CPBP family intramembrane metalloprotease -
AM609_RS05305 1308076..1308300 - 225 WP_020991564.1 helix-turn-helix transcriptional regulator -
AM609_RS05310 1308300..1309145 - 846 WP_053586441.1 ABC transporter permease -
AM609_RS05315 1309142..1309999 - 858 WP_053586442.1 ABC transporter ATP-binding protein -
AM609_RS05320 1310449..1310817 + 369 WP_053586443.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12382.49 Da        Isoelectric Point: 10.6530

>T56757 WP_053586438.1 NZ_CP012590:c1306790-1306443 [Actinomyces sp. oral taxon 414]
MLRGEIRVVNLEPVVGSEADKRRPAVIVSNDDANATAAMLGRGVVTIVPITSSTERVLPFQVLLPAEMTGLSRDSKAQAE
QVRSVAVQRLGRVIGRLPTEFMALLDAALRLHLAL

Download         Length: 348 bp

>T56757 NZ_CP012590:c1306790-1306443 [Actinomyces sp. oral taxon 414]
ATGCTGCGCGGTGAGATCCGCGTGGTGAACCTCGAGCCCGTCGTCGGCAGTGAGGCGGACAAGCGTCGACCGGCCGTGAT
CGTAAGCAACGACGACGCCAACGCCACCGCGGCAATGCTGGGGCGGGGCGTCGTCACGATCGTGCCGATCACGAGCTCGA
CGGAGCGCGTCCTGCCCTTCCAGGTTCTTCTCCCGGCGGAGATGACCGGCTTGTCGCGGGACTCCAAGGCCCAGGCCGAA
CAGGTGCGCTCCGTCGCCGTCCAGAGGCTCGGCCGGGTCATCGGACGGCTGCCCACCGAGTTCATGGCGCTCCTTGACGC
CGCGCTCAGGCTCCACCTCGCGCTGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9261.06 Da        Isoelectric Point: 4.4388

>AT56757 WP_053586439.1 NZ_CP012590:c1307025-1306777 [Actinomyces sp. oral taxon 414]
MKVSVSLDQADLEILDRYVEREGLASRSAGVRTAIRRLHRKDLREAYALAWREWDDSGTASDWESTVADGLDGDDEDNHA
AR

Download         Length: 249 bp

>AT56757 NZ_CP012590:c1307025-1306777 [Actinomyces sp. oral taxon 414]
ATGAAAGTAAGCGTGAGCCTGGATCAGGCAGACCTGGAGATCCTCGACCGGTACGTCGAGCGCGAGGGGCTCGCGTCGAG
ATCGGCCGGGGTCCGGACCGCGATCCGCCGTCTTCACCGGAAGGATCTGCGGGAGGCGTACGCGCTGGCGTGGCGGGAAT
GGGACGACTCCGGCACCGCGTCGGACTGGGAGAGCACCGTCGCCGACGGCCTGGACGGGGATGACGAGGACAACCATGCT
GCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4H4U8

Antitoxin

Source ID Structure
AlphaFold DB A0A0M4GDV0

References