Detailed information of TA system TA056756

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 274845..275416
• Replicon: chromosome
• Accession: NZ_CP012590
• Organism: Actinomyces sp. oral taxon 414 strain F0588

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0M4GAI9
• Locus tag: AM609_RS01025
• Protein ID: WP_053585782.1
• Coordinates: 274845..275222 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: AM609_RS01030
• Protein ID: WP_053585783.1
• Coordinates: 275219..275416 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM609_RS01015	269923..271770	+	1848	WP_053585780.1	phosphoenolpyruvate carboxykinase (GTP)	-
AM609_RS01020	272009..273070	-	1062	WP_053585781.1	NAD(P)-dependent alcohol dehydrogenase	-
AM609_RS16165	274469..274606	-	138	WP_157065831.1	hypothetical protein	-
AM609_RS01025	274845..275222	-	378	WP_053585782.1	type II toxin-antitoxin system VapC family toxin	Toxin
AM609_RS01030	275219..275416	-	198	WP_053585783.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
AM609_RS01035	275670..277986	-	2317	Protein_212	TerD family protein	-
AM609_RS01040	278095..279432	-	1338	WP_053585784.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-108)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (2-42)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13745.84 Da
• Isoelectric Point: 6.0935

>T56756 WP_053585782.1 NZ_CP012590:c275222-274845 [Actinomyces sp. oral taxon 414]
VILVDTSVWIDHFHRSDPVLVNLLHEDEIGAHPLVAEELAMGSLKARDDVLKHLAHLHQFPVLSHDELLALVAVHALWGR
GLSPVDAHLLGSVMLVPGARLWTRDKRLLCATEEHGVSFVEGPNG

Nucleotide

• Length: 378 bp

>T56756 NZ_CP012590:c275222-274845 [Actinomyces sp. oral taxon 414]
GTGATCCTTGTCGACACCTCGGTATGGATCGATCATTTCCACCGCTCGGACCCAGTACTCGTCAACCTGCTGCACGAGGA
CGAGATCGGGGCCCATCCACTCGTGGCGGAGGAGCTGGCGATGGGGTCACTCAAAGCCAGAGATGACGTCCTCAAGCACT
TGGCGCACCTCCACCAGTTCCCGGTCCTCTCACATGACGAGCTACTGGCTCTGGTCGCGGTCCATGCACTGTGGGGCCGA
GGGCTCAGCCCAGTCGATGCGCACCTGCTCGGCTCCGTCATGCTGGTCCCTGGCGCCCGTCTGTGGACACGCGACAAGCG
ATTGCTCTGCGCTACCGAGGAGCACGGAGTCTCCTTCGTCGAGGGGCCCAACGGCTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 6963.88 Da
• Isoelectric Point: 11.6072

>AT56756 WP_053585783.1 NZ_CP012590:c275416-275219 [Actinomyces sp. oral taxon 414]
VRTTVTLSDDLIASAQELTGITERTELLRAGLETLIRVESARRLAALGGSDRKASAAPRRRSASQ

Nucleotide

• Length: 198 bp

>AT56756 NZ_CP012590:c275416-275219 [Actinomyces sp. oral taxon 414]
GTGCGAACCACTGTGACACTCAGTGATGACCTCATTGCCAGCGCTCAGGAGCTCACGGGCATCACCGAGCGCACCGAGCT
GCTGCGGGCCGGCCTGGAGACCCTGATCAGGGTGGAGAGCGCACGTCGCCTTGCGGCTCTCGGCGGCTCTGACCGGAAGG
CGAGCGCCGCTCCACGACGTCGGAGCGCCAGCCAGTGA

Structures

Toxin

• AlphaFold DB: A0A0M4GAI9