Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 144779..145284 Replicon chromosome
Accession NZ_CP012584
Organism Pseudomonas aeruginosa strain PA_D25

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag A6704_RS00640 Protein ID WP_003121619.1
Coordinates 144779..145060 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag A6704_RS00645 Protein ID WP_003112628.1
Coordinates 145057..145284 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6704_RS00615 140030..141379 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
A6704_RS00620 141428..142114 + 687 WP_003083762.1 FadR family transcriptional regulator -
A6704_RS00625 142215..142949 + 735 WP_003110658.1 GntR family transcriptional regulator -
A6704_RS00630 143153..143539 + 387 WP_003083767.1 aegerolysin family protein -
A6704_RS00635 143571..144479 - 909 WP_003083769.1 LysR family transcriptional regulator -
A6704_RS00640 144779..145060 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
A6704_RS00645 145057..145284 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
A6704_RS00650 145460..146080 - 621 WP_003101226.1 hypothetical protein -
A6704_RS00655 146181..146681 + 501 WP_003101228.1 LEA type 2 family protein -
A6704_RS00660 146754..147095 + 342 WP_003101229.1 alkylphosphonate utilization protein -
A6704_RS00665 147177..148604 - 1428 WP_003083784.1 GABA permease -
A6704_RS00670 148773..150266 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T56741 WP_003121619.1 NZ_CP012584:c145060-144779 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T56741 NZ_CP012584:c145060-144779 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT56741 WP_003112628.1 NZ_CP012584:c145284-145057 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT56741 NZ_CP012584:c145284-145057 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References