Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4663769..4664285 Replicon chromosome
Accession NZ_CP012568
Organism Klebsiella pneumoniae strain UCLAOXA232KP

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag AM278_RS24295 Protein ID WP_002886902.1
Coordinates 4664001..4664285 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag AM278_RS24290 Protein ID WP_002886901.1
Coordinates 4663769..4664011 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM278_RS24275 4659797..4660537 + 741 WP_002886899.1 KDGP aldolase family protein -
AM278_RS24280 4660604..4661758 + 1155 WP_023302389.1 lactonase family protein -
AM278_RS24285 4661781..4663691 + 1911 WP_009486549.1 BglG family transcription antiterminator -
AM278_RS24290 4663769..4664011 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AM278_RS24295 4664001..4664285 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM278_RS24300 4664289..4664753 - 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AM278_RS24305 4665062..4667200 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
AM278_RS24315 4667557..4668300 - 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
AM278_RS31910 4668303..4668476 - 174 WP_032410138.1 hypothetical protein -
AM278_RS24325 4668561..4668869 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T56696 WP_002886902.1 NZ_CP012568:4664001-4664285 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T56696 NZ_CP012568:4664001-4664285 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT56696 WP_002886901.1 NZ_CP012568:4663769-4664011 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT56696 NZ_CP012568:4663769-4664011 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References