Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 1708643..1709300 | Replicon | chromosome |
Accession | NZ_CP012561 | ||
Organism | Klebsiella pneumoniae strain UCLAOXA232KP |
Toxin (Protein)
Gene name | cptA | Uniprot ID | W8UCT0 |
Locus tag | AM277_RS08815 | Protein ID | WP_002916310.1 |
Coordinates | 1708890..1709300 (+) | Length | 137 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | W8UQ37 |
Locus tag | AM277_RS08810 | Protein ID | WP_002916312.1 |
Coordinates | 1708643..1708909 (+) | Length | 89 a.a. |
Genomic Context
Location: 1706129..1706440 (312 bp)
Type: Others
Protein ID: WP_004144734.1
Type: Others
Protein ID: WP_004144734.1
Location: 1706604..1707263 (660 bp)
Type: Others
Protein ID: WP_002916317.1
Type: Others
Protein ID: WP_002916317.1
Location: 1708643..1708909 (267 bp)
Type: Antitoxin
Protein ID: WP_002916312.1
Type: Antitoxin
Protein ID: WP_002916312.1
Location: 1708890..1709300 (411 bp)
Type: Toxin
Protein ID: WP_002916310.1
Type: Toxin
Protein ID: WP_002916310.1
Location: 1709929..1710825 (897 bp)
Type: Others
Protein ID: WP_004144729.1
Type: Others
Protein ID: WP_004144729.1
Location: 1710848..1711561 (714 bp)
Type: Others
Protein ID: WP_004185548.1
Type: Others
Protein ID: WP_004185548.1
Location: 1711567..1713300 (1734 bp)
Type: Others
Protein ID: WP_004149758.1
Type: Others
Protein ID: WP_004149758.1
Location: 1703799..1705232 (1434 bp)
Type: Others
Protein ID: WP_002916322.1
Type: Others
Protein ID: WP_002916322.1
Location: 1705351..1706079 (729 bp)
Type: Others
Protein ID: WP_002916321.1
Type: Others
Protein ID: WP_002916321.1
Location: 1707414..1708397 (984 bp)
Type: Others
Protein ID: WP_004185555.1
Type: Others
Protein ID: WP_004185555.1
Location: 1709307..1709828 (522 bp)
Type: Others
Protein ID: WP_004144730.1
Type: Others
Protein ID: WP_004144730.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AM277_RS08785 | 1703799..1705232 | - | 1434 | WP_002916322.1 | 6-phospho-beta-glucosidase BglA | - |
AM277_RS08790 | 1705351..1706079 | - | 729 | WP_002916321.1 | MurR/RpiR family transcriptional regulator | - |
AM277_RS08795 | 1706129..1706440 | + | 312 | WP_004144734.1 | N(4)-acetylcytidine aminohydrolase | - |
AM277_RS08800 | 1706604..1707263 | + | 660 | WP_002916317.1 | hemolysin III family protein | - |
AM277_RS08805 | 1707414..1708397 | - | 984 | WP_004185555.1 | tRNA-modifying protein YgfZ | - |
AM277_RS08810 | 1708643..1708909 | + | 267 | WP_002916312.1 | FAD assembly factor SdhE | Antitoxin |
AM277_RS08815 | 1708890..1709300 | + | 411 | WP_002916310.1 | protein YgfX | Toxin |
AM277_RS08820 | 1709307..1709828 | - | 522 | WP_004144730.1 | flavodoxin FldB | - |
AM277_RS08825 | 1709929..1710825 | + | 897 | WP_004144729.1 | site-specific tyrosine recombinase XerD | - |
AM277_RS08830 | 1710848..1711561 | + | 714 | WP_004185548.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
AM277_RS08835 | 1711567..1713300 | + | 1734 | WP_004149758.1 | single-stranded-DNA-specific exonuclease RecJ | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 137 a.a. Molecular weight: 16049.85 Da Isoelectric Point: 11.4778
>T56665 WP_002916310.1 NZ_CP012561:1708890-1709300 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE
Download Length: 411 bp
>T56665 NZ_CP012561:1708890-1709300 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10480.98 Da Isoelectric Point: 5.1116
>AT56665 WP_002916312.1 NZ_CP012561:1708643-1708909 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI
Download Length: 267 bp
>AT56665 NZ_CP012561:1708643-1708909 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GSW7 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GY41 |