Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1708643..1709300 Replicon chromosome
Accession NZ_CP012561
Organism Klebsiella pneumoniae strain UCLAOXA232KP

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag AM277_RS08815 Protein ID WP_002916310.1
Coordinates 1708890..1709300 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag AM277_RS08810 Protein ID WP_002916312.1
Coordinates 1708643..1708909 (+) Length 89 a.a.

Genomic Context


AM277_RS08795AM277_RS08800AM277_RS08810AM277_RS08815AM277_RS08825AM277_RS08830AM277_RS08835AM277_RS08785AM277_RS08790AM277_RS08805AM277_RS08820
Location: 1706129..1706440 (312 bp)
Type: Others
Protein ID: WP_004144734.1
Location: 1706604..1707263 (660 bp)
Type: Others
Protein ID: WP_002916317.1
Location: 1708643..1708909 (267 bp)
Type: Antitoxin
Protein ID: WP_002916312.1
Location: 1708890..1709300 (411 bp)
Type: Toxin
Protein ID: WP_002916310.1
Location: 1709929..1710825 (897 bp)
Type: Others
Protein ID: WP_004144729.1
Location: 1710848..1711561 (714 bp)
Type: Others
Protein ID: WP_004185548.1
Location: 1711567..1713300 (1734 bp)
Type: Others
Protein ID: WP_004149758.1
Location: 1703799..1705232 (1434 bp)
Type: Others
Protein ID: WP_002916322.1
Location: 1705351..1706079 (729 bp)
Type: Others
Protein ID: WP_002916321.1
Location: 1707414..1708397 (984 bp)
Type: Others
Protein ID: WP_004185555.1
Location: 1709307..1709828 (522 bp)
Type: Others
Protein ID: WP_004144730.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AM277_RS087851703799..1705232-1434WP_002916322.16-phospho-beta-glucosidase BglA-
AM277_RS087901705351..1706079-729WP_002916321.1MurR/RpiR family transcriptional regulator-
AM277_RS087951706129..1706440+312WP_004144734.1N(4)-acetylcytidine aminohydrolase-
AM277_RS088001706604..1707263+660WP_002916317.1hemolysin III family protein-
AM277_RS088051707414..1708397-984WP_004185555.1tRNA-modifying protein YgfZ-
AM277_RS088101708643..1708909+267WP_002916312.1FAD assembly factor SdhEAntitoxin
AM277_RS088151708890..1709300+411WP_002916310.1protein YgfXToxin
AM277_RS088201709307..1709828-522WP_004144730.1flavodoxin FldB-
AM277_RS088251709929..1710825+897WP_004144729.1site-specific tyrosine recombinase XerD-
AM277_RS088301710848..1711561+714WP_004185548.1bifunctional protein-disulfide isomerase/oxidoreductase DsbC-
AM277_RS088351711567..1713300+1734WP_004149758.1single-stranded-DNA-specific exonuclease RecJ-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-132)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T56665 WP_002916310.1 NZ_CP012561:1708890-1709300 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T56665 NZ_CP012561:1708890-1709300 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT56665 WP_002916312.1 NZ_CP012561:1708643-1708909 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT56665 NZ_CP012561:1708643-1708909 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3GSW7


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3GY41

References