Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1594991..1595611 Replicon chromosome
Accession NZ_CP012554
Organism Citrobacter portucalensis strain P10159

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag P10159_RS07745 Protein ID WP_002892050.1
Coordinates 1595393..1595611 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag P10159_RS07740 Protein ID WP_003021733.1
Coordinates 1594991..1595365 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P10159_RS07730 1590137..1591330 + 1194 WP_003831044.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P10159_RS07735 1591353..1594502 + 3150 WP_008783964.1 multidrug efflux RND transporter permease subunit -
P10159_RS07740 1594991..1595365 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
P10159_RS07745 1595393..1595611 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
P10159_RS07750 1595793..1596344 + 552 WP_060682647.1 maltose O-acetyltransferase -
P10159_RS07755 1596461..1596931 + 471 WP_060682648.1 YlaC family protein -
P10159_RS07760 1597010..1597150 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
P10159_RS07765 1597152..1597412 - 261 WP_008783961.1 type B 50S ribosomal protein L31 -
P10159_RS07770 1597601..1599154 + 1554 WP_032942548.1 EAL domain-containing protein -
P10159_RS07775 1599206..1599559 - 354 WP_008783959.1 DUF1428 family protein -
P10159_RS07780 1599642..1600253 - 612 WP_060682649.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T56627 WP_002892050.1 NZ_CP012554:1595393-1595611 [Citrobacter portucalensis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T56627 NZ_CP012554:1595393-1595611 [Citrobacter portucalensis]
ATGTCCGATAAACCATTAACTAAAACAGATTATTTGATGCGCCTGCGACGTTGCCAGACAATTGATACGCTAGAGCGCGT
TATTGAAAAAAATAAATATGAATTGTCCGACAACGAACTGGCTGTATTTTACTCAGCAGCAGATCATCGCCTTGCTGAAT
TGACCATGAATAAGCTTTACGACAAGATTCCAACTTCTGTTTGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT56627 WP_003021733.1 NZ_CP012554:1594991-1595365 [Citrobacter portucalensis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT56627 NZ_CP012554:1594991-1595365 [Citrobacter portucalensis]
ATGGATGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAATTTCTCTGCGAAACTCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGTAACCATGGCTGGGTTAATGACCCTACCTCTGCAACCAGCTTGCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATCGCGCAGATAGATGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGTATTAATACGCAGGATCTGCAGAAATGGCGGAAGTCAGGTAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References