Detailed information of TA system TA056621

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 1462001..1462503
• Replicon: chromosome
• Accession: NZ_CP012548
• Organism: Campylobacter pinnipediorum subsp. pinnipediorum strain RM17262

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CPIN17262_RS07220
• Protein ID: WP_078388067.1
• Coordinates: 1462228..1462503 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: CPIN17262_RS07215
• Protein ID: WP_078388066.1
• Coordinates: 1462001..1462231 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPIN17262_RS07200	1458205..1458420	-	216	WP_078406242.1	DUF4492 domain-containing protein	-
CPIN17262_RS07205	1458583..1460214	+	1632	WP_078406243.1	CTP synthase	-
CPIN17262_RS07210	1460204..1461775	+	1572	WP_078406332.1	single-stranded-DNA-specific exonuclease RecJ	-
CPIN17262_RS07215	1462001..1462231	+	231	WP_078388066.1	ribbon-helix-helix domain-containing protein	Antitoxin
CPIN17262_RS07220	1462228..1462503	+	276	WP_078388067.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CPIN17262_RS07225	1462860..1466123	-	3264	WP_078406244.1	carbamoyl-phosphate synthase large subunit	-
CPIN17262_RS07230	1466123..1466878	-	756	WP_069633277.1	rod shape-determining protein MreC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-83)

Antitoxin

• Relaxosome protein TraY (3-35)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10431.23 Da
• Isoelectric Point: 10.1278

>T56621 WP_078388067.1 NZ_CP012548:1462228-1462503 [Campylobacter pinnipediorum subsp. pinnipediorum]
MKISFSKNALKEVKKLDKSVGIKILKKLKEIESLDNPRDEGKPLVGNLSGLWRYRVGGYRIICKIKDHELIVLILGIKNR
NNAYDSEFDSE

Nucleotide

• Length: 276 bp

>T56621 NZ_CP012548:1462228-1462503 [Campylobacter pinnipediorum subsp. pinnipediorum]
ATGAAAATAAGTTTTAGTAAAAATGCATTAAAAGAGGTTAAAAAGCTAGATAAGAGTGTTGGTATTAAAATACTTAAAAA
GTTAAAAGAAATAGAAAGTTTAGACAATCCTCGCGATGAAGGTAAACCTCTTGTCGGAAATTTATCTGGTCTTTGGAGAT
ATAGAGTTGGGGGATATAGAATAATATGCAAGATAAAAGATCACGAACTTATAGTGCTTATACTAGGCATTAAAAACAGG
AATAATGCTTACGATAGTGAGTTTGATAGCGAATAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8972.26 Da
• Isoelectric Point: 4.6583

>AT56621 WP_078388066.1 NZ_CP012548:1462001-1462231 [Campylobacter pinnipediorum subsp. pinnipediorum]
MQISVRLDKDIGNKLERLAKDTKRTKSFYVQEAIKRFLEDMNDYMYAVEELKKIENDPNPEFYALDEVAKDLGINL

Nucleotide

• Length: 231 bp

>AT56621 NZ_CP012548:1462001-1462231 [Campylobacter pinnipediorum subsp. pinnipediorum]
ATGCAAATTTCAGTTAGATTAGATAAAGATATAGGAAACAAGCTTGAGAGATTAGCAAAAGATACAAAAAGAACAAAAAG
CTTTTATGTCCAAGAAGCTATAAAAAGATTCTTAGAAGATATGAATGACTATATGTATGCAGTAGAAGAGTTAAAAAAAA
TAGAAAATGATCCTAATCCAGAATTTTATGCCTTAGATGAAGTAGCCAAAGATCTTGGCATAAACCTATGA