Detailed information of TA system TA056619

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 881777..882353
• Replicon: chromosome
• Accession: NZ_CP012547
• Organism: Campylobacter pinnipediorum subsp. pinnipediorum strain RM17261

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: CPIN17261_RS04425
• Protein ID: WP_078387706.1
• Coordinates: 881777..882076 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CPIN17261_RS04430
• Protein ID: WP_078387707.1
• Coordinates: 882069..882353 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPIN17261_RS04385	876860..877201	+	342	WP_078387698.1	hypothetical protein	-
CPIN17261_RS04390	877203..877508	+	306	WP_194284709.1	hypothetical protein	-
CPIN17261_RS04395	877546..878748	+	1203	WP_078387700.1	hypothetical protein	-
CPIN17261_RS04400	878738..878923	+	186	WP_078387701.1	hypothetical protein	-
CPIN17261_RS04405	878913..879443	+	531	WP_078387702.1	hypothetical protein	-
CPIN17261_RS04410	879454..879678	+	225	WP_078387703.1	hypothetical protein	-
CPIN17261_RS04415	879669..881372	+	1704	WP_078387704.1	AAA family ATPase	-
CPIN17261_RS04420	881460..881669	-	210	WP_078387705.1	hypothetical protein	-
CPIN17261_RS04425	881777..882076	+	300	WP_078387706.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CPIN17261_RS04430	882069..882353	+	285	WP_078387707.1	putative addiction module antidote protein	Antitoxin
CPIN17261_RS04435	882356..883357	-	1002	WP_153300937.1	hypothetical protein	-
CPIN17261_RS04445	883700..884782	-	1083	WP_078387710.1	phage tail tape measure protein	-
CPIN17261_RS04450	884859..885041	+	183	WP_078387711.1	hypothetical protein	-
CPIN17261_RS04455	885146..885409	-	264	WP_078387712.1	hypothetical protein	-
CPIN17261_RS04460	885480..885974	-	495	WP_078387713.1	phage major tail tube protein	-
CPIN17261_RS04465	885979..886227	-	249	WP_078387714.1	hypothetical protein	-
CPIN17261_RS04470	886230..886466	-	237	WP_078387715.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	863364..913542	50178

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (21-93)

Antitoxin

• Uncharacterized protein HI1420 (3-93)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11373.05 Da
• Isoelectric Point: 9.6254

>T56619 WP_078387706.1 NZ_CP012547:881777-882076 [Campylobacter pinnipediorum subsp. pinnipediorum]
MYTIKQTDYFSKWIIKLKDIKGKVSILRRVERIKDGNFGDCKSVGNNISELRITTGPGYRVYYTNKNDEIIILLVGGDKS
TQSNDIKKANEILKDLENE

Nucleotide

• Length: 300 bp

>T56619 NZ_CP012547:881777-882076 [Campylobacter pinnipediorum subsp. pinnipediorum]
ATGTATACAATAAAACAAACTGATTACTTTTCAAAATGGATAATAAAGCTTAAAGACATAAAGGGTAAAGTTTCAATTTT
GCGAAGAGTTGAAAGAATAAAAGACGGCAATTTTGGAGATTGTAAATCAGTTGGTAACAATATAAGCGAACTAAGAATTA
CAACTGGTCCAGGATATAGAGTTTATTACACAAATAAAAACGATGAGATTATTATTTTATTAGTTGGCGGGGATAAATCA
ACTCAAAGTAATGATATTAAAAAAGCAAATGAAATTTTAAAGGATTTAGAAAATGAGTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10394.93 Da
• Isoelectric Point: 5.0477

>AT56619 WP_078387707.1 NZ_CP012547:882069-882353 [Campylobacter pinnipediorum subsp. pinnipediorum]
MSKTQITDFDISQYLDNQEVIAEYISQILADGDMDELLDALGNIAKAKGMSQIAKDTGLGRESLYKTFHKGSKPKFDTIM
KLISSFGLKMQVSA

Nucleotide

• Length: 285 bp

>AT56619 NZ_CP012547:882069-882353 [Campylobacter pinnipediorum subsp. pinnipediorum]
ATGAGTAAAACACAAATAACGGATTTTGATATATCTCAGTATTTAGACAATCAAGAAGTCATAGCAGAATATATATCTCA
AATCTTAGCCGATGGTGATATGGATGAGCTACTAGATGCGCTTGGCAATATAGCAAAAGCCAAAGGCATGAGCCAAATAG
CAAAAGACACAGGGCTGGGCAGAGAAAGTTTATATAAAACCTTTCACAAAGGAAGTAAGCCAAAGTTTGATACTATAATG
AAACTTATATCTTCTTTTGGTTTAAAAATGCAAGTTAGCGCATAA