Detailed information of TA system TA056602

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2830..3364
• Replicon: plasmid pPSB1-3
• Accession: NZ_CP012511
• Organism: Piscirickettsia salmonis strain PM32597B1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KU39_RS16330
• Protein ID: WP_048876199.1
• Coordinates: 3074..3364 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1L6TI86
• Locus tag: KU39_RS16325
• Protein ID: WP_027243211.1
• Coordinates: 2830..3084 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU39_RS16310	1..978	-	978	WP_036771347.1	IS5 family transposase	-
KU39_RS16315	1174..1362	+	189	Protein_1	hypothetical protein	-
KU39_RS16320	1459..2436	+	978	WP_036771347.1	IS5 family transposase	-
KU39_RS21085	2451..2612	+	162	WP_155046636.1	hypothetical protein	-
KU39_RS16325	2830..3084	+	255	WP_027243211.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KU39_RS16330	3074..3364	+	291	WP_048876199.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KU39_RS16335	3351..4328	-	978	WP_036771347.1	IS5 family transposase	-
KU39_RS16340	4661..5155	-	495	Protein_7	hypothetical protein	-
KU39_RS20225	5124..5240	-	117	Protein_8	phage minor tail protein L	-
KU39_RS16345	5329..5541	+	213	WP_053093683.1	hypothetical protein	-
KU39_RS16350	5699..6676	+	978	WP_036771347.1	IS5 family transposase	-
KU39_RS16355	6691..7275	+	585	WP_053856780.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..181035	181035

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-78)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-55)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11119.33 Da
• Isoelectric Point: 10.5762

>T56602 WP_048876199.1 NZ_CP012511:3074-3364 [Piscirickettsia salmonis]
MTYKLQFHKEAYKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYKIKLRALGYRLIYTVKKDKVVVQVLARR
CCVTSGPIFQAQFSCV

Nucleotide

• Length: 291 bp

>T56602 NZ_CP012511:3074-3364 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGTATAAAGAGTGGAAAAAACTAAATCCAACAACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCATCAGCAGTGTGTGGTGGTGATTTAAAAGGCTGCTATAAAA
TTAAATTAAGAGCGCTCGGTTATCGTTTAATTTATACAGTGAAAAAGGACAAAGTGGTTGTTCAAGTCTTGGCCAGGCGT
TGTTGCGTAACCTCTGGTCCCATATTCCAGGCACAATTCAGCTGCGTCTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9554.83 Da
• Isoelectric Point: 4.3176

>AT56602 WP_027243211.1 NZ_CP012511:2830-3084 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLHSPDRDFIDVD
VDDL

Nucleotide

• Length: 255 bp

>AT56602 NZ_CP012511:2830-3084 [Piscirickettsia salmonis]
ATGAAACAGCTCTACGCACAACAGTCGGTAACAATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATCAATGAAGCCAA
CGGCGAACCGGTGGTTATTTTGAATCATAATGTTCCTGCGGCGTACATGGTGCCACCTGAACTTTTTGAAGCCATGCTCG
ACTCGTATGAAGACCGCCAACTTGAAGGCATAGTCAAAAAACGTTTACATTCTCCTGACCGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A1L6TI86