Detailed information of TA system TA056538

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 2117545..2118169
• Replicon: chromosome
• Accession: NZ_CP012503
• Organism: Streptococcus agalactiae strain NGBS357

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A076ZDW1
• Locus tag: AMR84_RS10570
• Protein ID: WP_000253103.1
• Coordinates: 2117545..2117892 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A076YVN5
• Locus tag: AMR84_RS10575
• Protein ID: WP_000543070.1
• Coordinates: 2117882..2118169 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AMR84_RS10550	2113260..2113616	-	357	WP_000105934.1	DUF1304 domain-containing protein	-
AMR84_RS10555	2113683..2116001	-	2319	WP_000883414.1	YhgE/Pip domain-containing protein	-
AMR84_RS10560	2116140..2116679	+	540	WP_000245858.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-
AMR84_RS10565	2116765..2117061	-	297	WP_001052249.1	DUF4298 domain-containing protein	-
AMR84_RS10570	2117545..2117892	-	348	WP_000253103.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AMR84_RS10575	2117882..2118169	-	288	WP_000543070.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
AMR84_RS10580	2118238..2118615	-	378	WP_000038826.1	DUF1492 domain-containing protein	-
AMR84_RS11580	2118590..2118742	-	153	Protein_2031	DUF1492 domain-containing protein	-
AMR84_RS10585	2118749..2119237	-	489	WP_000891151.1	hypothetical protein	-
AMR84_RS10590	2119310..2119867	-	558	WP_001258765.1	hypothetical protein	-
AMR84_RS10595	2120025..2120198	-	174	WP_000694573.1	hypothetical protein	-
AMR84_RS10600	2120195..2120452	-	258	WP_001069293.1	hypothetical protein	-
AMR84_RS10605	2120745..2122139	-	1395	WP_000656430.1	hypothetical protein	-
AMR84_RS10610	2122151..2123008	-	858	WP_001029296.1	primase alpha helix C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2116765..2154395	37630

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (12-108)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-63)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13333.09 Da
• Isoelectric Point: 5.1643

>T56538 WP_000253103.1 NZ_CP012503:c2117892-2117545 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK

Nucleotide

• Length: 348 bp

>T56538 NZ_CP012503:c2117892-2117545 [Streptococcus agalactiae]
TTGGTATCTGATAATAAAACCCATAGCCTTATTATCCCTGAAACCGTACAAGAACAATTACAGGAGATAAAAAGCTATAT
TGAAACTACTTACTTTTCGGAGCAGGCAGGGGCTAACACCGTCAACAATATTCTTTACGGGCTAGAACGTCTTGAATTTT
TCCCAGAAGCAGGATTTAACGCAGATGACAGAGTAGGTGAAACTATTTACCCGCCACATAATACTCGTTGTATTGTTTTA
GGGGACTACCTAGCTTTTTATCACATTTTAGAAGACAGAAAAGCCGTTTTTGTATCTGATATTATCCATAGCAAACAAGA
CTATATCAAACTGTTTAAGAAAAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10605.98 Da
• Isoelectric Point: 4.8430

>AT56538 WP_000543070.1 NZ_CP012503:c2118169-2117882 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Nucleotide

• Length: 288 bp

>AT56538 NZ_CP012503:c2118169-2117882 [Streptococcus agalactiae]
ATGCACGCTTTAGAAAAAAATACGCAGGTCAACTTTAAAACCAACAGTGATTTACTAGAGAAAGCTAAAGCTATTATCGC
AGCCCAAAACCTTGACATGACAGCTAGCTTTAATTTGTTTTTAGAAAACATTGTACAAAATAAAGCCTTACCTTTTGAGA
CTGACACCGATAAAGAACGAGCTGAACTACTTGCAGGTTTACGAGCTGAAATTGCTAAAAGTTTTGACGATTTAGAGCAT
GGGCGGGTATACAACGCTAGTGAAGTGAGGGCTAACCTTGGTATCTGA

Structures

Toxin

• AlphaFold DB: A0A076ZDW1

Antitoxin

• AlphaFold DB: A0A076YVN5