Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 239394..240006 Replicon chromosome
Accession NZ_CP012503
Organism Streptococcus agalactiae strain NGBS357

Toxin (Protein)


Gene name parE Uniprot ID Q8E1X3
Locus tag AMR84_RS01395 Protein ID WP_000384858.1
Coordinates 239394..239729 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E1X2
Locus tag AMR84_RS01400 Protein ID WP_000255538.1
Coordinates 239719..240006 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AMR84_RS01370 234592..235221 + 630 WP_000591148.1 hypothetical protein -
AMR84_RS01375 235534..236409 + 876 WP_000770113.1 hypothetical protein -
AMR84_RS01380 236445..236879 + 435 WP_001220479.1 hypothetical protein -
AMR84_RS01385 237195..238451 + 1257 WP_000122832.1 plasmid recombination protein -
AMR84_RS01390 238619..239089 + 471 WP_000130119.1 hypothetical protein -
AMR84_RS01395 239394..239729 - 336 WP_000384858.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AMR84_RS01400 239719..240006 - 288 WP_000255538.1 hypothetical protein Antitoxin
AMR84_RS01405 240513..240803 + 291 WP_000078283.1 WXG100 family type VII secretion target -
AMR84_RS01410 240905..241312 + 408 WP_000749954.1 hypothetical protein -
AMR84_RS11585 241312..241871 + 560 Protein_227 hypothetical protein -
AMR84_RS01420 241844..242524 + 681 WP_001865565.1 hypothetical protein -
AMR84_RS01425 242509..242895 + 387 WP_000259069.1 hypothetical protein -
AMR84_RS01430 242929..243210 + 282 WP_000052406.1 hypothetical protein -
AMR84_RS01445 244053..244913 + 861 WP_000477654.1 Rgg/GadR/MutR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13264.04 Da        Isoelectric Point: 5.2388

>T56537 WP_000384858.1 NZ_CP012503:c239729-239394 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

>T56537 NZ_CP012503:c239729-239394 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGTTAAAGGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCGACATCAGGTCAGCACAAAATGGAGCAAATCATTAGTGACATAGAAAAACTCGAGGTTTTCCCTGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTAAGTACCACAGCACTAGAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGAGGAAGAGAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10921.47 Da        Isoelectric Point: 4.7271

>AT56537 WP_000255538.1 NZ_CP012503:c240006-239719 [Streptococcus agalactiae]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp

>AT56537 NZ_CP012503:c240006-239719 [Streptococcus agalactiae]
ATGGTTACAGCAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAGAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTTCAAAATGTCGTTGTCACAAATGAGGTTGACTTATTGA
CGGAAGAGGAGCTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAAGATGTTCGTCAA
GGGAAATTTTATACCTCTGAAGAAGTGAGGTCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1EF10

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1EFF9

References