Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 38871..39393 Replicon plasmid pCFSAN004179G
Accession NZ_CP012501
Organism Escherichia coli strain 08-00022

Toxin (Protein)


Gene name relE Uniprot ID A0A0B0VZI6
Locus tag CP48_RS00300 Protein ID WP_000220565.1
Coordinates 39112..39393 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0B0W3C1
Locus tag CP48_RS00295 Protein ID WP_000121742.1
Coordinates 38871..39122 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP48_RS31025 34634..34714 + 81 Protein_48 hypothetical protein -
CP48_RS00285 36055..37057 + 1003 Protein_50 IS3 family transposase -
CP48_RS00290 37577..38596 + 1020 WP_024166190.1 IS110 family transposase -
CP48_RS00295 38871..39122 + 252 WP_000121742.1 hypothetical protein Antitoxin
CP48_RS00300 39112..39393 + 282 WP_000220565.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CP48_RS00305 39876..40939 + 1064 Protein_54 IS256 family transposase -
CP48_RS00310 40939..41792 - 854 Protein_55 IS3 family transposase -
CP48_RS31030 41852..42007 + 156 Protein_56 ISKra4 family transposase -
CP48_RS00320 43284..43505 + 222 WP_032287374.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - estIa / faeC / faeD / faeE / faeF / faeH / faeI / faeJ / stcE / exeE / exeG / hlyD / hlyB / hlyA / hlyC / estIa / estIa 1..242187 242187
- inside IScluster/Tn - - 19702..41792 22090


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11037.83 Da        Isoelectric Point: 10.5938

>T56528 WP_000220565.1 NZ_CP012501:39112-39393 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLSERLENPRVPAARLHGHADRYKIKLRSSGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T56528 NZ_CP012501:39112-39393 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGTCAGAACGGCTGGAAAATCCACGTGTACCTGCAGCCCGATTACATGGTCATGCTGATCGTTATAAAATCA
AACTTCGTTCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGAGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9181.47 Da        Isoelectric Point: 4.2958

>AT56528 WP_000121742.1 NZ_CP012501:38871-39122 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKKPEIVKVSL
DDL

Download         Length: 252 bp

>AT56528 NZ_CP012501:38871-39122 [Escherichia coli]
ATGAGTTATCAAATCCTGACAACCACAGCGGCCAGTATTACTGACCTAAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GAGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAAACCGGAAATTGTGAAGGTTAGCCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B0VZI6

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0W3C1

References