Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 69106..69665 Replicon plasmid pCFSAN004178P_02
Accession NZ_CP012498
Organism Escherichia coli strain 06-00048 isolate CFSAN004178

Toxin (Protein)


Gene name relE Uniprot ID A0A193M1T8
Locus tag GJ11_RS01170 Protein ID WP_024221843.1
Coordinates 69390..69665 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A193M1S9
Locus tag GJ11_RS01165 Protein ID WP_024221844.1
Coordinates 69106..69390 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJ11_RS01140 64460..65332 - 873 Protein_68 IS3 family transposase -
GJ11_RS01145 67021..67609 - 589 Protein_69 hypothetical protein -
GJ11_RS01150 67725..67994 - 270 Protein_70 integrase core domain-containing protein -
GJ11_RS01155 67983..68388 - 406 Protein_71 hypothetical protein -
GJ11_RS01160 68495..68716 + 222 WP_001261037.1 MarR family transcriptional regulator -
GJ11_RS01165 69106..69390 + 285 WP_024221844.1 ribbon-helix-helix protein, CopG family Antitoxin
GJ11_RS01170 69390..69665 + 276 WP_024221843.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GJ11_RS01175 69771..70052 + 282 WP_065226038.1 hypothetical protein -
GJ11_RS01180 70299..71818 + 1520 WP_185762087.1 IS3 family transposase -
GJ11_RS01185 71901..73240 + 1340 WP_097463187.1 IS3 family transposase -
GJ11_RS01190 73762..74592 + 831 WP_065225954.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - estIa / hlyC / hlyA / hlyB / hlyD / estIa / draB / afaC-I 1..213847 213847


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10778.53 Da        Isoelectric Point: 9.9324

>T56493 WP_024221843.1 NZ_CP012498:69390-69665 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPVAARTVQSLTQAPIILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELTGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T56493 NZ_CP012498:69390-69665 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGT
GGCCGCCAGAACGGTGCAGTCCCTGACACAGGCACCGATCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10522.94 Da        Isoelectric Point: 5.0481

>AT56493 WP_024221844.1 NZ_CP012498:69106-69390 [Escherichia coli]
MQMKNNTAQATKVITAHVPLLMADKVDQMAARLERSRGWIIKQALSAWIAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLDTDNSLPVPR

Download         Length: 285 bp

>AT56493 NZ_CP012498:69106-69390 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACTTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGGTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGATTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCGATACTGACAATTCGTTACCGGTGCCTCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A193M1T8

Antitoxin

Source ID Structure
AlphaFold DB A0A193M1S9

References