Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/Txe-RelB
Location 209951..210458 Replicon chromosome
Accession NZ_CP012420
Organism Rickettsia amblyommatis strain Ac37

Toxin (Protein)


Gene name relB Uniprot ID H8K422
Locus tag AL573_RS01110 Protein ID WP_014391804.1
Coordinates 210195..210458 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID H8K421
Locus tag AL573_RS01105 Protein ID WP_014391803.1
Coordinates 209951..210202 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL573_RS01080 205119..206186 - 1068 WP_053350891.1 alanine racemase -
AL573_RS01085 206183..207214 - 1032 WP_053351138.1 ribose-phosphate diphosphokinase -
AL573_RS01090 207426..208025 - 600 WP_045800512.1 phospholipid-binding protein MlaC -
AL573_RS01095 208046..208801 - 756 WP_041860557.1 VacJ family lipoprotein -
AL573_RS01100 208806..209810 - 1005 WP_045800154.1 methyltransferase domain-containing protein -
AL573_RS01105 209951..210202 + 252 WP_014391803.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AL573_RS01110 210195..210458 + 264 WP_014391804.1 Txe/YoeB family addiction module toxin Toxin
AL573_RS01115 210518..211723 + 1206 WP_045800156.1 pyridoxal phosphate-dependent aminotransferase -
AL573_RS01120 211874..212530 + 657 WP_045800157.1 lysophospholipid acyltransferase family protein -
AL573_RS01125 212527..213921 + 1395 WP_053350892.1 lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase -
AL573_RS01130 213986..214414 - 429 WP_198400847.1 Sca4 family protein -
AL573_RS01135 214528..214932 - 405 Protein_238 hypothetical protein -
AL573_RS09530 215214..215333 - 120 WP_144010744.1 palindromic element RPE4 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10498.35 Da        Isoelectric Point: 9.6904

>T56455 WP_014391804.1 NZ_CP012420:210195-210458 [Rickettsia amblyommatis]
MIEIEWTLEAAEDLACWKKYDIKKYERIKLLIKNIQEAPFIGIGKPEALKHILSGLWSRRINHEHRLIYSVNTKQIIIYN
CRFHYKN

Download         Length: 264 bp

>T56455 NZ_CP012420:210195-210458 [Rickettsia amblyommatis]
ATGATTGAGATTGAGTGGACACTAGAAGCAGCGGAGGATTTAGCGTGTTGGAAAAAATATGATATTAAAAAATATGAACG
TATTAAACTTCTAATAAAAAATATCCAAGAAGCACCGTTTATAGGTATAGGTAAACCCGAAGCTTTAAAACATATATTAT
CAGGTTTATGGTCACGTAGAATTAACCACGAACATAGACTAATATATTCTGTCAATACTAAACAAATTATAATATATAAT
TGTAGATTTCATTATAAAAATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9521.77 Da        Isoelectric Point: 9.4884

>AT56455 WP_014391803.1 NZ_CP012420:209951-210202 [Rickettsia amblyommatis]
MNSISGTSFRKNLSSVLNTVENDHVPYLIKRKNHKNIILLTEEEYESTKETLYLLSNPANANRIKKSIEQAKRGEFAKVN
LDD

Download         Length: 252 bp

>AT56455 NZ_CP012420:209951-210202 [Rickettsia amblyommatis]
ATGAACTCAATTAGCGGCACTTCATTTAGAAAAAACTTAAGCTCTGTACTAAATACCGTAGAAAACGATCATGTCCCTTA
TCTTATTAAAAGAAAGAATCATAAGAATATTATTCTTTTAACCGAAGAAGAATATGAATCTACAAAAGAAACATTATATT
TATTATCTAATCCGGCTAATGCGAATCGAATAAAAAAATCTATCGAACAAGCAAAAAGAGGAGAGTTTGCTAAAGTTAAT
TTAGATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H8K422

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2M0P5

References