Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 56280..56803 Replicon chromosome
Accession NZ_CP012420
Organism Rickettsia amblyommatis strain Ac37

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag AL573_RS07705 Protein ID WP_082066679.1
Coordinates 56660..56803 (+) Length 48 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag AL573_RS00315 Protein ID WP_053350867.1
Coordinates 56280..56543 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL573_RS07685 51442..51561 + 120 WP_014391656.1 palindromic element RPE1 domain-containing protein -
AL573_RS00280 51613..52308 - 696 WP_014391657.1 TIGR02281 family clan AA aspartic protease -
AL573_RS09275 52425..52577 - 153 Protein_57 serine hydrolase -
AL573_RS07690 52605..52793 - 189 Protein_58 hypothetical protein -
AL573_RS00290 53116..53373 - 258 WP_081120818.1 serine hydrolase -
AL573_RS00295 53600..53833 - 234 Protein_60 type II toxin-antitoxin system Phd/YefM family antitoxin -
AL573_RS00300 54045..54767 - 723 WP_053350866.1 amino acid ABC transporter ATP-binding protein -
AL573_RS00305 54771..55535 - 765 WP_045800116.1 MBL fold metallo-hydrolase -
AL573_RS00310 55550..56197 + 648 WP_045800117.1 phosphatase PAP2 family protein -
AL573_RS00315 56280..56543 + 264 WP_053350867.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AL573_RS07705 56660..56803 + 144 WP_082066679.1 type II toxin-antitoxin system YafQ family toxin Toxin
AL573_RS00320 56939..58024 + 1086 WP_014391665.1 LptF/LptG family permease -
AL573_RS00325 58030..58494 - 465 WP_004997101.1 DNA polymerase III subunit chi -
AL573_RS00335 58694..59839 - 1146 WP_014391666.1 succinyl-diaminopimelate desuccinylase -
AL573_RS00340 59903..60435 - 533 Protein_69 restriction endonuclease subunit S -
AL573_RS09995 60457..60552 - 96 Protein_70 hypothetical protein -
AL573_RS00345 60518..60716 - 199 Protein_71 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-45)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5434.30 Da        Isoelectric Point: 7.2426

>T56454 WP_082066679.1 NZ_CP012420:56660-56803 [Rickettsia amblyommatis]
MRDHALIGNWKDCRDCHIKPDLVLIYRKPDADTLELIRLGSHSTLGF

Download         Length: 144 bp

>T56454 NZ_CP012420:56660-56803 [Rickettsia amblyommatis]
ATGAGAGATCATGCCCTTATAGGTAATTGGAAAGATTGTAGAGATTGTCATATTAAACCGGATTTAGTATTAATTTATAG
AAAACCCGATGCTGACACATTGGAGTTAATACGATTAGGTTCACACAGTACACTTGGTTTTTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9550.07 Da        Isoelectric Point: 5.0916

>AT56454 WP_053350867.1 NZ_CP012420:56280-56543 [Rickettsia amblyommatis]
MSADSIVRARINEDVKEEAALVLASMGLTLSDAVRMMLFRVAREKALPFEPLIPNDETIKAMKAARSGKLVHVGNINNLL
SDLNEND

Download         Length: 264 bp

>AT56454 NZ_CP012420:56280-56543 [Rickettsia amblyommatis]
ATGTCTGCTGATTCTATTGTGCGAGCCCGTATTAATGAAGACGTGAAAGAAGAAGCAGCTTTAGTGCTTGCTTCTATGGG
ACTTACTTTATCTGATGCTGTTCGTATGATGTTATTTCGTGTTGCTCGTGAAAAAGCATTGCCGTTTGAGCCACTTATCC
CAAATGATGAAACAATTAAAGCTATGAAAGCTGCAAGAAGCGGCAAATTAGTTCATGTTGGTAATATCAATAATTTGTTA
TCTGATTTAAATGAGAACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References