Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2452522..2453298 Replicon chromosome
Accession NZ_CP012409
Organism Staphylococcus aureus subsp. aureus Tager 104

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag Tgr_RS12405 Protein ID WP_000031108.1
Coordinates 2453146..2453298 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A6B1RP77
Locus tag Tgr_RS12400 Protein ID WP_001251218.1
Coordinates 2452522..2453121 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Tgr_RS12380 2448439..2449896 + 1458 WP_000649919.1 ABC transporter permease subunit -
Tgr_RS12385 2449889..2450611 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
Tgr_RS12390 2450761..2451888 + 1128 WP_000379982.1 tRNA epoxyqueuosine(34) reductase QueG -
Tgr_RS12395 2451893..2452363 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
Tgr_RS12400 2452522..2453121 + 600 WP_001251218.1 glucosamine-6-phosphate isomerase Antitoxin
Tgr_RS12405 2453146..2453298 + 153 WP_000031108.1 hypothetical protein Toxin
Tgr_RS12420 2453961..2454356 + 396 WP_029753550.1 hypothetical protein -
Tgr_RS12425 2454552..2455937 + 1386 WP_000116235.1 class II fumarate hydratase -
Tgr_RS12430 2456397..2457218 - 822 WP_000669380.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T56445 WP_000031108.1 NZ_CP012409:2453146-2453298 [Staphylococcus aureus subsp. aureus Tager 104]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T56445 NZ_CP012409:2453146-2453298 [Staphylococcus aureus subsp. aureus Tager 104]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT56445 WP_001251218.1 NZ_CP012409:2452522-2453121 [Staphylococcus aureus subsp. aureus Tager 104]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFIVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT56445 NZ_CP012409:2452522-2453121 [Staphylococcus aureus subsp. aureus Tager 104]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATTGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCATAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A6B1RP77

References