Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 732767..733244 Replicon chromosome
Accession NZ_CP012409
Organism Staphylococcus aureus subsp. aureus Tager 104

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag Tgr_RS03680 Protein ID WP_000052076.1
Coordinates 733056..733244 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag Tgr_RS03675 Protein ID WP_001059690.1
Coordinates 732767..733027 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Tgr_RS03640 728160..728876 - 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -
Tgr_RS03645 729024..729446 + 423 WP_000974455.1 organic hydroperoxide resistance protein -
Tgr_RS03650 729845..730339 + 495 WP_000569881.1 GNAT family N-acetyltransferase -
Tgr_RS03655 730494..731111 + 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
Tgr_RS03660 731184..731765 - 582 WP_001140696.1 phosphoglycerate mutase family protein -
Tgr_RS03665 731990..732226 + 237 WP_000368687.1 hypothetical protein -
Tgr_RS03670 732223..732426 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
Tgr_RS03675 732767..733027 + 261 WP_001059690.1 hypothetical protein Antitoxin
Tgr_RS03680 733056..733244 + 189 WP_000052076.1 hypothetical protein Toxin
Tgr_RS03685 733432..734001 + 570 WP_001106649.1 hypothetical protein -
Tgr_RS03690 734089..734373 + 285 WP_001004401.1 hypothetical protein -
Tgr_RS03695 734436..734654 + 219 WP_000005880.1 hypothetical protein -
Tgr_RS03700 735152..735352 - 201 WP_001059082.1 cold-shock protein -
Tgr_RS03705 735709..736395 - 687 WP_001813074.1 thermonuclease family protein -
Tgr_RS03710 736736..737257 - 522 WP_000824483.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T56432 WP_000052076.1 NZ_CP012409:733056-733244 [Staphylococcus aureus subsp. aureus Tager 104]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T56432 NZ_CP012409:733056-733244 [Staphylococcus aureus subsp. aureus Tager 104]
ATGTCTTTACATTTTGCAATTCTTTTTTGGCTAGCATTAATTTTTTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT56432 WP_001059690.1 NZ_CP012409:732767-733027 [Staphylococcus aureus subsp. aureus Tager 104]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT56432 NZ_CP012409:732767-733027 [Staphylococcus aureus subsp. aureus Tager 104]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References