56429

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 5022963..5023567 Replicon chromosome
Accession NZ_CP012400
Organism Pseudomonas yamanorum strain LBUM636

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag AK972_RS23875 Protein ID WP_063032679.1
Coordinates 5022963..5023256 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A1R0GAX7
Locus tag AK972_RS23880 Protein ID WP_003212064.1
Coordinates 5023259..5023567 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AK972_RS23835 5018666..5018878 + 213 WP_063032670.1 cysteine-rich CWC family protein -
AK972_RS23840 5018878..5019570 + 693 WP_063032672.1 pseudouridine synthase -
AK972_RS23845 5019876..5020760 + 885 WP_063032674.1 alpha/beta hydrolase -
AK972_RS23855 5021078..5021518 - 441 WP_063032676.1 GNAT family N-acetyltransferase -
AK972_RS23860 5021598..5021837 - 240 WP_063032677.1 hypothetical protein -
AK972_RS23870 5022478..5022801 + 324 Protein_4557 transcriptional regulator -
AK972_RS23875 5022963..5023256 + 294 WP_063032679.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AK972_RS23880 5023259..5023567 + 309 WP_003212064.1 putative addiction module antidote protein Antitoxin
AK972_RS23885 5023560..5024750 - 1191 WP_063032681.1 MFS transporter -
AK972_RS23890 5024747..5025910 - 1164 WP_063032683.1 MFS transporter -
AK972_RS23895 5026006..5026905 + 900 WP_063032685.1 LysR family transcriptional regulator -
AK972_RS23900 5026994..5027326 + 333 WP_063032687.1 hypothetical protein -
AK972_RS23905 5027416..5027898 + 483 WP_063032689.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
AK972_RS23910 5028007..5028432 + 426 WP_063032691.1 low affinity iron permease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(5-96)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10759.39 Da        Isoelectric Point: 11.0685

>T56429 WP_063032679.1 NZ_CP012400:5022963-5023256 [Pseudomonas yamanorum]
VNYLVQQTQTFITWHSAIRDLRAKIAIARRIDRASAGNLGDIKTVGNGVSEMRVDIGLGYRVYFTQRGRTVIVLLAGGDK
SSQDADIRRAKKLAKEV

Download         Length: 294 bp

>T56429 NZ_CP012400:5022963-5023256 [Pseudomonas yamanorum]
GTGAACTATCTTGTCCAGCAAACGCAGACCTTCATTACCTGGCATTCAGCAATACGTGATTTACGCGCAAAAATCGCCAT
CGCCCGGCGCATCGATCGCGCATCTGCTGGCAATCTGGGCGATATAAAGACGGTAGGCAATGGTGTCTCGGAAATGCGCG
TAGATATCGGTCTGGGTTATCGAGTGTATTTCACGCAGCGAGGAAGAACCGTCATCGTCTTGCTGGCCGGTGGCGACAAA
TCCTCACAAGACGCCGACATCCGGCGAGCAAAAAAACTGGCAAAGGAAGTTTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 10981.49 Da        Isoelectric Point: 5.0484

>AT56429 WP_003212064.1 NZ_CP012400:5023259-5023567 [Pseudomonas yamanorum]
MSQTLTTFDMAALLDSDEAISEYLSQVLADGDNEEFLRAVGYVAKARGMARVATDTGMGRESLYKAFAPGAKPRFETVLK
VLHALGIDLQAQPGHVANHSII

Download         Length: 309 bp

>AT56429 NZ_CP012400:5023259-5023567 [Pseudomonas yamanorum]
ATGAGCCAAACACTGACGACATTTGATATGGCAGCACTGCTCGACAGTGACGAAGCCATCAGCGAATACCTTTCTCAAGT
CCTGGCAGACGGCGATAACGAGGAGTTCCTCAGGGCCGTCGGGTACGTGGCCAAAGCTCGTGGAATGGCGCGGGTCGCGA
CCGATACGGGCATGGGCCGTGAAAGCCTGTACAAGGCATTTGCCCCTGGAGCAAAGCCCCGCTTCGAAACCGTACTTAAG
GTGCTTCACGCCCTGGGTATCGATCTGCAAGCGCAGCCGGGGCATGTCGCCAATCATTCGATTATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1R0GAX7

References