Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 4129421..4130641 | Replicon | chromosome |
| Accession | NZ_CP012400 | ||
| Organism | Pseudomonas yamanorum strain LBUM636 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A143GJS8 |
| Locus tag | AK972_RS19540 | Protein ID | WP_063031531.1 |
| Coordinates | 4130066..4130641 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A143GK94 |
| Locus tag | AK972_RS19535 | Protein ID | WP_063031529.1 |
| Coordinates | 4129421..4129978 (+) | Length | 186 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AK972_RS19515 | 4125320..4125976 | + | 657 | WP_063031521.1 | diguanylate cyclase | - |
| AK972_RS19520 | 4125973..4127202 | + | 1230 | WP_063031523.1 | pyridoxal phosphate-dependent aminotransferase | - |
| AK972_RS19525 | 4127306..4128637 | + | 1332 | WP_081253264.1 | MFS transporter | - |
| AK972_RS19530 | 4128663..4129325 | + | 663 | WP_063031527.1 | RraA family protein | - |
| AK972_RS19535 | 4129421..4129978 | + | 558 | WP_063031529.1 | helix-turn-helix domain-containing protein | Antitoxin |
| AK972_RS19540 | 4130066..4130641 | + | 576 | WP_063031531.1 | HD domain-containing protein | Toxin |
| AK972_RS19545 | 4130648..4132861 | - | 2214 | WP_063031533.1 | type II secretion system secretin GspD | - |
| AK972_RS19550 | 4132858..4133382 | - | 525 | WP_063031535.1 | general secretion pathway protein GspN | - |
| AK972_RS19555 | 4133379..4133990 | - | 612 | WP_023659000.1 | general secretion pathway protein GspM | - |
| AK972_RS19560 | 4133965..4135005 | - | 1041 | WP_063031537.1 | PilN domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21586.47 Da Isoelectric Point: 4.8589
>T56428 WP_063031531.1 NZ_CP012400:4130066-4130641 [Pseudomonas yamanorum]
MDIEKLKGRLEFLREAEKLKDVLRSAHTSSGRTESTAEHSWRLCLMAITFGDELAGLDLLKILKMCVIHDLGEAIHGDIP
AVNQAQFPNKSQQEHDDLLLLTRALDEPLRAEILALWDDYENAQSAEAKAVKALDKLETLLQHNQGLNPPDFDYAFNLAY
GKKHTSAEPIFQTLREIIDQDTEAKIQTPNR
MDIEKLKGRLEFLREAEKLKDVLRSAHTSSGRTESTAEHSWRLCLMAITFGDELAGLDLLKILKMCVIHDLGEAIHGDIP
AVNQAQFPNKSQQEHDDLLLLTRALDEPLRAEILALWDDYENAQSAEAKAVKALDKLETLLQHNQGLNPPDFDYAFNLAY
GKKHTSAEPIFQTLREIIDQDTEAKIQTPNR
Download Length: 576 bp
>T56428 NZ_CP012400:4130066-4130641 [Pseudomonas yamanorum]
ATGGACATCGAAAAACTCAAGGGCCGCCTCGAGTTCCTGCGCGAAGCGGAAAAACTCAAGGACGTGCTCAGAAGCGCGCA
TACCTCTTCCGGTCGCACCGAGAGCACCGCGGAACACAGCTGGCGCCTGTGCCTGATGGCAATTACCTTCGGGGATGAAC
TGGCCGGCCTCGACCTGCTGAAAATCCTCAAGATGTGCGTAATCCACGACCTGGGAGAGGCCATCCACGGCGACATCCCG
GCGGTCAACCAGGCGCAGTTCCCCAACAAGAGCCAGCAAGAACACGACGACCTGTTGCTGTTGACCCGGGCACTGGATGA
GCCGTTGCGGGCCGAGATTCTGGCCCTGTGGGACGACTACGAAAACGCCCAGTCCGCCGAGGCCAAGGCAGTCAAAGCCC
TGGACAAGCTGGAGACCCTGCTGCAACACAACCAGGGCTTGAACCCGCCCGACTTCGACTACGCCTTCAATCTGGCCTAT
GGCAAGAAACACACCAGCGCCGAGCCGATTTTCCAGACACTGCGCGAGATCATCGACCAGGATACAGAAGCAAAAATCCA
GACTCCCAACCGGTAG
ATGGACATCGAAAAACTCAAGGGCCGCCTCGAGTTCCTGCGCGAAGCGGAAAAACTCAAGGACGTGCTCAGAAGCGCGCA
TACCTCTTCCGGTCGCACCGAGAGCACCGCGGAACACAGCTGGCGCCTGTGCCTGATGGCAATTACCTTCGGGGATGAAC
TGGCCGGCCTCGACCTGCTGAAAATCCTCAAGATGTGCGTAATCCACGACCTGGGAGAGGCCATCCACGGCGACATCCCG
GCGGTCAACCAGGCGCAGTTCCCCAACAAGAGCCAGCAAGAACACGACGACCTGTTGCTGTTGACCCGGGCACTGGATGA
GCCGTTGCGGGCCGAGATTCTGGCCCTGTGGGACGACTACGAAAACGCCCAGTCCGCCGAGGCCAAGGCAGTCAAAGCCC
TGGACAAGCTGGAGACCCTGCTGCAACACAACCAGGGCTTGAACCCGCCCGACTTCGACTACGCCTTCAATCTGGCCTAT
GGCAAGAAACACACCAGCGCCGAGCCGATTTTCCAGACACTGCGCGAGATCATCGACCAGGATACAGAAGCAAAAATCCA
GACTCCCAACCGGTAG
Antitoxin
Download Length: 186 a.a. Molecular weight: 20554.71 Da Isoelectric Point: 7.4483
>AT56428 WP_063031529.1 NZ_CP012400:4129421-4129978 [Pseudomonas yamanorum]
MSDLLLKPALPGIALRRWRLLHRVKQAHAAELFNVTQSTISRWESGVQAMEPAAHQHLEQLLAARLEAAADQALARLVKE
SPRPMHLVCDLTHRLLACSASRAAEFSSPLTDLLGHSLWRFVTPEILRMESALDESGWRDSLAPPALEFITGTNDSTVVP
IRQSLCRWTRIPLSDGTAARLVETL
MSDLLLKPALPGIALRRWRLLHRVKQAHAAELFNVTQSTISRWESGVQAMEPAAHQHLEQLLAARLEAAADQALARLVKE
SPRPMHLVCDLTHRLLACSASRAAEFSSPLTDLLGHSLWRFVTPEILRMESALDESGWRDSLAPPALEFITGTNDSTVVP
IRQSLCRWTRIPLSDGTAARLVETL
Download Length: 558 bp
>AT56428 NZ_CP012400:4129421-4129978 [Pseudomonas yamanorum]
ATGTCCGACCTATTGCTCAAGCCTGCCCTGCCCGGCATTGCGCTGAGACGATGGCGTCTGCTGCACCGCGTCAAACAGGC
TCACGCCGCCGAGTTGTTCAACGTCACCCAGTCGACCATTTCCCGCTGGGAAAGTGGTGTGCAGGCCATGGAGCCTGCAG
CGCACCAACACCTTGAACAGTTGCTGGCCGCACGCCTGGAGGCCGCCGCCGATCAGGCCCTCGCTCGGCTGGTCAAGGAA
AGTCCGCGCCCGATGCACCTGGTGTGTGACCTGACCCACCGTTTGTTGGCTTGCTCGGCCTCCCGTGCTGCCGAGTTCAG
CAGCCCGTTGACCGACCTGCTGGGGCATTCGCTGTGGCGCTTCGTGACGCCGGAAATCCTGCGCATGGAATCCGCGCTGG
ATGAATCGGGCTGGCGCGACAGCCTCGCCCCGCCGGCCCTGGAGTTCATCACCGGCACCAACGATTCCACGGTTGTGCCG
ATCCGCCAGAGCCTGTGCCGCTGGACCCGCATCCCGCTGAGCGATGGCACCGCCGCGCGGCTGGTCGAGACGCTCTAA
ATGTCCGACCTATTGCTCAAGCCTGCCCTGCCCGGCATTGCGCTGAGACGATGGCGTCTGCTGCACCGCGTCAAACAGGC
TCACGCCGCCGAGTTGTTCAACGTCACCCAGTCGACCATTTCCCGCTGGGAAAGTGGTGTGCAGGCCATGGAGCCTGCAG
CGCACCAACACCTTGAACAGTTGCTGGCCGCACGCCTGGAGGCCGCCGCCGATCAGGCCCTCGCTCGGCTGGTCAAGGAA
AGTCCGCGCCCGATGCACCTGGTGTGTGACCTGACCCACCGTTTGTTGGCTTGCTCGGCCTCCCGTGCTGCCGAGTTCAG
CAGCCCGTTGACCGACCTGCTGGGGCATTCGCTGTGGCGCTTCGTGACGCCGGAAATCCTGCGCATGGAATCCGCGCTGG
ATGAATCGGGCTGGCGCGACAGCCTCGCCCCGCCGGCCCTGGAGTTCATCACCGGCACCAACGATTCCACGGTTGTGCCG
ATCCGCCAGAGCCTGTGCCGCTGGACCCGCATCCCGCTGAGCGATGGCACCGCCGCGCGGCTGGTCGAGACGCTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A143GJS8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A143GK94 |