Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 1629280..1629894 | Replicon | chromosome |
Accession | NZ_CP012400 | ||
Organism | Pseudomonas yamanorum strain LBUM636 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | A0A1R0GDL0 |
Locus tag | AK972_RS07950 | Protein ID | WP_026077965.1 |
Coordinates | 1629280..1629468 (+) | Length | 63 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A1R0GDH6 |
Locus tag | AK972_RS07955 | Protein ID | WP_017477502.1 |
Coordinates | 1629490..1629894 (+) | Length | 135 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AK972_RS07925 | 1625026..1625745 | + | 720 | WP_063028155.1 | phosphonate C-P lyase system protein PhnL | - |
AK972_RS07930 | 1625735..1626883 | + | 1149 | WP_063028157.1 | alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase | - |
AK972_RS07935 | 1626883..1627446 | + | 564 | WP_063028160.1 | phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN | - |
AK972_RS07940 | 1627437..1628186 | + | 750 | WP_063028162.1 | phosphonate metabolism protein PhnP | - |
AK972_RS07945 | 1628183..1629064 | - | 882 | WP_063028164.1 | LysR family transcriptional regulator | - |
AK972_RS07950 | 1629280..1629468 | + | 189 | WP_026077965.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
AK972_RS07955 | 1629490..1629894 | + | 405 | WP_017477502.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
AK972_RS07960 | 1629895..1631091 | - | 1197 | WP_081253098.1 | MFS transporter | - |
AK972_RS07965 | 1631270..1631884 | + | 615 | WP_017477504.1 | hypothetical protein | - |
AK972_RS07970 | 1632026..1633030 | - | 1005 | WP_063028168.1 | sulfate ABC transporter substrate-binding protein | - |
AK972_RS07975 | 1633136..1633960 | - | 825 | WP_017477506.1 | ion transporter | - |
AK972_RS07980 | 1633992..1634867 | - | 876 | WP_063028171.1 | urea transporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7196.40 Da Isoelectric Point: 11.2000
>T56426 WP_026077965.1 NZ_CP012400:1629280-1629468 [Pseudomonas yamanorum]
VQSRLLIKELQEAGWVLDRVTGSHHLFTHRYNPYTIPVPHPKKDLPMGTVRSIRKRAGLFSF
VQSRLLIKELQEAGWVLDRVTGSHHLFTHRYNPYTIPVPHPKKDLPMGTVRSIRKRAGLFSF
Download Length: 189 bp
>T56426 NZ_CP012400:1629280-1629468 [Pseudomonas yamanorum]
GTGCAAAGCAGGCTATTGATCAAAGAGCTGCAAGAGGCAGGTTGGGTGCTGGATCGGGTGACGGGCAGCCATCATCTTTT
CACCCACCGCTATAACCCGTACACGATACCGGTGCCCCATCCCAAGAAGGATCTGCCCATGGGCACCGTGCGAAGTATCA
GGAAACGTGCCGGGCTGTTTTCGTTTTAG
GTGCAAAGCAGGCTATTGATCAAAGAGCTGCAAGAGGCAGGTTGGGTGCTGGATCGGGTGACGGGCAGCCATCATCTTTT
CACCCACCGCTATAACCCGTACACGATACCGGTGCCCCATCCCAAGAAGGATCTGCCCATGGGCACCGTGCGAAGTATCA
GGAAACGTGCCGGGCTGTTTTCGTTTTAG
Antitoxin
Download Length: 135 a.a. Molecular weight: 14804.88 Da Isoelectric Point: 4.5011
>AT56426 WP_017477502.1 NZ_CP012400:1629490-1629894 [Pseudomonas yamanorum]
MQYPICIEWGDDFVATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHIMLQEIAAEGRVIPMPTSVAAHHDNEDYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRL
MQYPICIEWGDDFVATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHIMLQEIAAEGRVIPMPTSVAAHHDNEDYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRL
Download Length: 405 bp
>AT56426 NZ_CP012400:1629490-1629894 [Pseudomonas yamanorum]
ATGCAATACCCAATCTGTATCGAATGGGGCGATGACTTTGTCGCCACCGGTATCCAGATCCCCGACATTCCAGGTGCGGT
GACCGCCGGGGACAGTTTTGAAGAGGCTTACAACGCGGCGGTTGAAGTGGCGCACATCATGCTGCAAGAGATCGCCGCAG
AAGGCCGGGTGATTCCGATGCCAACGTCGGTGGCCGCCCATCACGATAATGAGGATTACGCCGGCATGGGCTGGGGAATG
TTGGAGCTCGACATCTCGCCGTATCTGGGCAAGACCGAGAAGGTCAACGTGACCTTGCCCGGCTATGTGATCCAGCGTAT
CGACCGTTATGTGCGGGAGCACAAAGTGAAAAGCCGCTCGTCATTTCTGGCCGATGCGGCTTTGGAGAAATTGGTGCGGT
TGTAA
ATGCAATACCCAATCTGTATCGAATGGGGCGATGACTTTGTCGCCACCGGTATCCAGATCCCCGACATTCCAGGTGCGGT
GACCGCCGGGGACAGTTTTGAAGAGGCTTACAACGCGGCGGTTGAAGTGGCGCACATCATGCTGCAAGAGATCGCCGCAG
AAGGCCGGGTGATTCCGATGCCAACGTCGGTGGCCGCCCATCACGATAATGAGGATTACGCCGGCATGGGCTGGGGAATG
TTGGAGCTCGACATCTCGCCGTATCTGGGCAAGACCGAGAAGGTCAACGTGACCTTGCCCGGCTATGTGATCCAGCGTAT
CGACCGTTATGTGCGGGAGCACAAAGTGAAAAGCCGCTCGTCATTTCTGGCCGATGCGGCTTTGGAGAAATTGGTGCGGT
TGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1R0GDL0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1R0GDH6 |