56426

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1629280..1629894 Replicon chromosome
Accession NZ_CP012400
Organism Pseudomonas yamanorum strain LBUM636

Toxin (Protein)


Gene name hicA Uniprot ID A0A1R0GDL0
Locus tag AK972_RS07950 Protein ID WP_026077965.1
Coordinates 1629280..1629468 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1R0GDH6
Locus tag AK972_RS07955 Protein ID WP_017477502.1
Coordinates 1629490..1629894 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AK972_RS07925 1625026..1625745 + 720 WP_063028155.1 phosphonate C-P lyase system protein PhnL -
AK972_RS07930 1625735..1626883 + 1149 WP_063028157.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
AK972_RS07935 1626883..1627446 + 564 WP_063028160.1 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN -
AK972_RS07940 1627437..1628186 + 750 WP_063028162.1 phosphonate metabolism protein PhnP -
AK972_RS07945 1628183..1629064 - 882 WP_063028164.1 LysR family transcriptional regulator -
AK972_RS07950 1629280..1629468 + 189 WP_026077965.1 type II toxin-antitoxin system HicA family toxin Toxin
AK972_RS07955 1629490..1629894 + 405 WP_017477502.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AK972_RS07960 1629895..1631091 - 1197 WP_081253098.1 MFS transporter -
AK972_RS07965 1631270..1631884 + 615 WP_017477504.1 hypothetical protein -
AK972_RS07970 1632026..1633030 - 1005 WP_063028168.1 sulfate ABC transporter substrate-binding protein -
AK972_RS07975 1633136..1633960 - 825 WP_017477506.1 ion transporter -
AK972_RS07980 1633992..1634867 - 876 WP_063028171.1 urea transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7196.40 Da        Isoelectric Point: 11.2000

>T56426 WP_026077965.1 NZ_CP012400:1629280-1629468 [Pseudomonas yamanorum]
VQSRLLIKELQEAGWVLDRVTGSHHLFTHRYNPYTIPVPHPKKDLPMGTVRSIRKRAGLFSF

Download         Length: 189 bp

>T56426 NZ_CP012400:1629280-1629468 [Pseudomonas yamanorum]
GTGCAAAGCAGGCTATTGATCAAAGAGCTGCAAGAGGCAGGTTGGGTGCTGGATCGGGTGACGGGCAGCCATCATCTTTT
CACCCACCGCTATAACCCGTACACGATACCGGTGCCCCATCCCAAGAAGGATCTGCCCATGGGCACCGTGCGAAGTATCA
GGAAACGTGCCGGGCTGTTTTCGTTTTAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14804.88 Da        Isoelectric Point: 4.5011

>AT56426 WP_017477502.1 NZ_CP012400:1629490-1629894 [Pseudomonas yamanorum]
MQYPICIEWGDDFVATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHIMLQEIAAEGRVIPMPTSVAAHHDNEDYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRL

Download         Length: 405 bp

>AT56426 NZ_CP012400:1629490-1629894 [Pseudomonas yamanorum]
ATGCAATACCCAATCTGTATCGAATGGGGCGATGACTTTGTCGCCACCGGTATCCAGATCCCCGACATTCCAGGTGCGGT
GACCGCCGGGGACAGTTTTGAAGAGGCTTACAACGCGGCGGTTGAAGTGGCGCACATCATGCTGCAAGAGATCGCCGCAG
AAGGCCGGGTGATTCCGATGCCAACGTCGGTGGCCGCCCATCACGATAATGAGGATTACGCCGGCATGGGCTGGGGAATG
TTGGAGCTCGACATCTCGCCGTATCTGGGCAAGACCGAGAAGGTCAACGTGACCTTGCCCGGCTATGTGATCCAGCGTAT
CGACCGTTATGTGCGGGAGCACAAAGTGAAAAGCCGCTCGTCATTTCTGGCCGATGCGGCTTTGGAGAAATTGGTGCGGT
TGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R0GDL0

Antitoxin

Source ID Structure
AlphaFold DB A0A1R0GDH6

References