Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2918223..2918863 Replicon chromosome
Accession NZ_CP012398
Organism Chelatococcus sp. CO-6

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag AL346_RS24685 Protein ID WP_026014823.1
Coordinates 2918223..2918519 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag AL346_RS13740 Protein ID WP_019400443.1
Coordinates 2918558..2918863 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL346_RS13720 2913418..2914362 - 945 WP_053193775.1 sugar ABC transporter substrate-binding protein -
AL346_RS13725 2914557..2915375 - 819 WP_053193777.1 MurR/RpiR family transcriptional regulator -
AL346_RS13730 2915462..2916580 + 1119 WP_019400445.1 Gfo/Idh/MocA family oxidoreductase -
AL346_RS13735 2916633..2918012 + 1380 WP_019400444.1 HTH domain-containing protein -
AL346_RS24685 2918223..2918519 + 297 WP_026014823.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL346_RS13740 2918558..2918863 + 306 WP_019400443.1 putative addiction module antidote protein Antitoxin
AL346_RS13755 2919526..2919795 - 270 WP_019400442.1 hypothetical protein -
AL346_RS13760 2919909..2922008 - 2100 WP_019400441.1 S9 family peptidase -
AL346_RS13765 2922005..2922421 - 417 WP_026014822.1 peptide-methionine (R)-S-oxide reductase -
AL346_RS13770 2922804..2923235 + 432 WP_019400439.1 MucR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(52-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10968.70 Da        Isoelectric Point: 10.5743

>T56425 WP_026014823.1 NZ_CP012398:2918223-2918519 [Chelatococcus sp. CO-6]
MIELIKSATFDRWLRSLRDRRTVARIQARLDRLAGGNPGDVKPVGGGISEMRIDYGPGYRVYYMQRGPIVVILLSGGDKS
SQRADIAKAMEMAAQWKD

Download         Length: 297 bp

>T56425 NZ_CP012398:2918223-2918519 [Chelatococcus sp. CO-6]
ATGATCGAGTTGATCAAGAGCGCCACGTTCGATCGCTGGCTCCGTAGCTTGCGCGACAGACGGACCGTGGCACGCATCCA
GGCGAGACTTGATCGACTTGCAGGTGGAAATCCCGGCGATGTCAAACCCGTCGGAGGCGGCATTTCCGAGATGCGGATCG
ATTATGGACCTGGCTATCGAGTCTATTACATGCAGAGAGGGCCAATTGTTGTCATCCTGCTTTCCGGCGGTGACAAGTCT
TCGCAAAGAGCTGACATCGCCAAGGCTATGGAAATGGCCGCGCAGTGGAAGGATTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10971.35 Da        Isoelectric Point: 4.8232

>AT56425 WP_019400443.1 NZ_CP012398:2918558-2918863 [Chelatococcus sp. CO-6]
MLSGKSETFSRYDTADYLKNDEDILAYLEAVMEEGGDDPAYIARALGVVARARNMSQLARDTGLSREGLYKALSEDGNPT
FATIVKVAHALGLRVSFRPAA

Download         Length: 306 bp

>AT56425 NZ_CP012398:2918558-2918863 [Chelatococcus sp. CO-6]
ATGCTTTCCGGAAAAAGCGAGACCTTCAGCCGATATGATACGGCAGACTATCTCAAGAACGACGAAGATATCCTTGCTTA
CCTGGAAGCGGTGATGGAGGAAGGTGGCGACGATCCCGCCTATATCGCGCGTGCGCTCGGCGTCGTTGCCCGCGCGCGCA
ACATGAGCCAGCTCGCGCGCGATACCGGGTTGAGCCGCGAGGGGCTCTACAAGGCTCTTTCAGAAGACGGCAATCCCACC
TTTGCCACGATTGTGAAAGTCGCGCACGCGCTGGGATTGCGGGTAAGCTTCAGACCGGCCGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References