Detailed information of TA system TA056424

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2843995..2844662
• Replicon: chromosome
• Accession: NZ_CP012398
• Organism: Chelatococcus sp. CO-6

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AL346_RS13390
• Protein ID: WP_026015006.1
• Coordinates: 2843995..2844393 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A840BPX5
• Locus tag: AL346_RS13395
• Protein ID: WP_019401460.1
• Coordinates: 2844393..2844662 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL346_RS13365	2839731..2840030	-	300	WP_156332755.1	hypothetical protein	-
AL346_RS13370	2840132..2840782	-	651	WP_082312514.1	GNAT family acetyltransferase	-
AL346_RS13380	2842002..2843267	-	1266	WP_040403875.1	class I SAM-dependent RNA methyltransferase	-
AL346_RS13385	2843260..2843985	-	726	WP_019401458.1	TlyA family RNA methyltransferase	-
AL346_RS13390	2843995..2844393	-	399	WP_026015006.1	type II toxin-antitoxin system VapC family toxin	Toxin
AL346_RS13395	2844393..2844662	-	270	WP_019401460.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
AL346_RS13400	2845105..2847012	-	1908	WP_019401461.1	1-deoxy-D-xylulose-5-phosphate synthase	-
AL346_RS13405	2847106..2848023	-	918	WP_019401462.1	pirin family protein	-
AL346_RS13410	2848046..2848297	-	252	WP_026015007.1	exodeoxyribonuclease VII small subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-125)

Antitoxin

• Antitoxin VapB-like (1-81)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14165.05 Da
• Isoelectric Point: 6.4547

>T56424 WP_026015006.1 NZ_CP012398:c2844393-2843995 [Chelatococcus sp. CO-6]
IVVDTSAFIAMLTNEPEAEALALALYGAGARYVSAVTVYETRVVLLRRGDARYFIPFGNLLTSANLVLHTFDTAQSNLAS
DAYRRFGRGSGHPARLNLGDCASYALAMSLDAPLLYKGNDFSQTDVRSALAA

Nucleotide

• Length: 399 bp

>T56424 NZ_CP012398:c2844393-2843995 [Chelatococcus sp. CO-6]
ATCGTCGTCGATACGTCGGCCTTCATCGCCATGCTCACCAATGAGCCGGAAGCCGAAGCGCTCGCTCTGGCGCTCTATGG
CGCCGGCGCCCGCTACGTCTCGGCTGTAACGGTCTATGAAACACGGGTCGTCCTGCTGCGGCGAGGCGATGCTCGCTATT
TCATCCCCTTCGGCAATCTGCTCACCAGCGCCAATCTCGTCCTGCACACCTTCGATACGGCTCAGTCCAATCTCGCGAGC
GACGCCTACCGTCGCTTCGGCCGCGGCTCCGGCCATCCGGCACGGCTCAACCTCGGCGACTGTGCGTCCTATGCGCTCGC
CATGTCGCTCGACGCGCCGCTGCTCTATAAGGGCAACGACTTCTCGCAGACGGACGTGCGCTCCGCGCTCGCCGCATAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10262.67 Da
• Isoelectric Point: 4.5728

>AT56424 WP_019401460.1 NZ_CP012398:c2844662-2844393 [Chelatococcus sp. CO-6]
MALNIKSAETERLAREVAALTGETITEAVRKALEMRLEQAREEREKEIARQMAALRVIQEDVRRLGPLPKITKRDFDELW
GELDDGEQE

Nucleotide

• Length: 270 bp

>AT56424 NZ_CP012398:c2844662-2844393 [Chelatococcus sp. CO-6]
ATGGCCCTCAACATCAAATCCGCCGAGACGGAGCGTCTCGCCCGCGAGGTCGCGGCGCTCACCGGCGAGACGATCACCGA
AGCCGTGCGCAAGGCGCTCGAAATGCGCCTCGAACAGGCGCGGGAGGAGCGGGAGAAGGAAATCGCGCGCCAGATGGCCG
CTTTGCGCGTGATTCAGGAGGATGTCCGGCGCCTCGGTCCGCTGCCGAAGATCACGAAACGTGATTTCGACGAGTTGTGG
GGCGAACTTGACGACGGCGAGCAGGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A840BPX5