Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1776515..1777047 Replicon chromosome
Accession NZ_CP012398
Organism Chelatococcus sp. CO-6

Toxin (Protein)


Gene name mazF Uniprot ID A0A840BUV3
Locus tag AL346_RS08360 Protein ID WP_019400500.1
Coordinates 1776515..1776838 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A840BZP3
Locus tag AL346_RS08365 Protein ID WP_019400499.1
Coordinates 1776835..1777047 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL346_RS08335 1772255..1773040 + 786 WP_019400505.1 3-hydroxybutyrate dehydrogenase -
AL346_RS08340 1773037..1774140 + 1104 WP_019400504.1 patatin-like phospholipase family protein -
AL346_RS08345 1774162..1774707 + 546 WP_019400503.1 O-acetyl-ADP-ribose deacetylase -
AL346_RS08350 1774710..1775369 - 660 WP_019400502.1 methyltransferase -
AL346_RS08355 1775366..1776493 - 1128 Protein_1663 glycosyltransferase -
AL346_RS08360 1776515..1776838 - 324 WP_019400500.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AL346_RS08365 1776835..1777047 - 213 WP_019400499.1 antitoxin MazE family protein Antitoxin
AL346_RS08370 1777117..1778643 - 1527 WP_053193519.1 altronate dehydratase family protein -
AL346_RS08375 1778745..1779194 - 450 WP_019402752.1 hypothetical protein -
AL346_RS08380 1779218..1780252 - 1035 WP_019402753.1 aldo/keto reductase -
AL346_RS08385 1780264..1781559 - 1296 WP_019402754.1 TRAP transporter large permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

Antitoxin MazE-like

(6-68)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11588.53 Da        Isoelectric Point: 9.9933

>T56422 WP_019400500.1 NZ_CP012398:c1776838-1776515 [Chelatococcus sp. CO-6]
MRRGDLVTVALPGAYGKPRPALIVQSDLFSTHPSFTLLPVTSELVAAPLLRITVEPNERNGLQKVSQIMVDKAHTVPRGK
VGEPFGRLDETDLLAVNRALALFLGFA

Download         Length: 324 bp

>T56422 NZ_CP012398:c1776838-1776515 [Chelatococcus sp. CO-6]
ATGAGGCGCGGTGATCTCGTCACCGTGGCTCTTCCCGGGGCCTATGGCAAACCCAGACCGGCCCTGATCGTCCAGTCGGA
TCTCTTCAGCACGCATCCCTCCTTCACCTTGCTGCCGGTGACGAGTGAACTCGTCGCGGCGCCGCTCCTGCGCATCACGG
TCGAGCCGAACGAGCGCAACGGCCTGCAGAAGGTCTCGCAGATCATGGTCGACAAGGCTCACACGGTGCCCCGCGGCAAG
GTGGGCGAGCCTTTCGGCCGGCTCGACGAGACGGACCTTCTCGCGGTAAACCGCGCGCTCGCGCTCTTTCTCGGCTTTGC
GTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 8050.13 Da        Isoelectric Point: 7.1679

>AT56422 WP_019400499.1 NZ_CP012398:c1777047-1776835 [Chelatococcus sp. CO-6]
MAGVAKRVQRHRERLRAAGLKPVQIWIPDPAQPGFAEECRRQSQLIAKSAEEDEILDFIEAVSDHRGWRE

Download         Length: 213 bp

>AT56422 NZ_CP012398:c1777047-1776835 [Chelatococcus sp. CO-6]
ATGGCAGGTGTCGCCAAGCGCGTGCAGCGCCATCGCGAGCGATTGCGGGCGGCCGGGCTGAAGCCGGTGCAGATCTGGAT
ACCGGACCCGGCGCAGCCCGGCTTTGCCGAGGAATGCCGGCGCCAGTCGCAACTCATCGCCAAGAGCGCCGAGGAAGACG
AGATCCTCGATTTCATCGAAGCGGTCTCGGACCATCGGGGCTGGCGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A840BUV3

Antitoxin

Source ID Structure
AlphaFold DB A0A840BZP3

References