Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 130365..130942 Replicon chromosome
Accession NZ_CP012398
Organism Chelatococcus sp. CO-6

Toxin (Protein)


Gene name vapC Uniprot ID A0A840C5N9
Locus tag AL346_RS00755 Protein ID WP_019403243.1
Coordinates 130559..130942 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A840C454
Locus tag AL346_RS00750 Protein ID WP_019403242.1
Coordinates 130365..130562 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL346_RS00725 126474..126965 + 492 WP_019403237.1 MaoC family dehydratase -
AL346_RS00730 126971..127846 + 876 WP_026015318.1 CoA ester lyase -
AL346_RS00735 127944..128552 - 609 WP_019403239.1 flavin reductase family protein -
AL346_RS00740 128558..129130 - 573 WP_019403240.1 nitroreductase -
AL346_RS00745 129422..130267 + 846 WP_156332819.1 hypothetical protein -
AL346_RS00750 130365..130562 + 198 WP_019403242.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
AL346_RS00755 130559..130942 + 384 WP_019403243.1 PIN domain-containing protein Toxin
AL346_RS00760 130998..132989 - 1992 WP_019403244.1 threonine--tRNA ligase -
AL346_RS00765 133042..133410 - 369 WP_019403245.1 membrane protein insertion efficiency factor YidD -
AL346_RS00770 133604..134389 + 786 WP_157672263.1 MipA/OmpV family protein -
AL346_RS00775 134415..134870 - 456 WP_019403247.1 iron-sulfur cluster assembly scaffold protein -
AL346_RS00780 135063..135719 + 657 WP_019403248.1 GTP cyclohydrolase I FolE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-46)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13741.90 Da        Isoelectric Point: 6.2121

>T56421 WP_019403243.1 NZ_CP012398:130559-130942 [Chelatococcus sp. CO-6]
MILVDTSVWVDHLRTGEETLAALLDHGRVLTHPFVIGELALGFLRQRQAILPALQGLPHASLATDAEVLAFIDEHALAGL
GIGYVDAHLLASTRLTAGSTLWSRDKRLARVAERLELAWQGGLLPPP

Download         Length: 384 bp

>T56421 NZ_CP012398:130559-130942 [Chelatococcus sp. CO-6]
ATGATCCTCGTCGATACGTCGGTTTGGGTCGATCACCTGCGCACCGGCGAGGAAACGCTTGCCGCCTTGCTCGATCATGG
CCGCGTGTTGACGCATCCGTTTGTCATCGGGGAGCTGGCACTCGGCTTCCTGCGCCAGCGCCAGGCAATCCTCCCGGCGC
TTCAAGGGCTACCGCACGCAAGTCTCGCCACCGATGCCGAAGTGCTGGCGTTCATCGACGAGCACGCGCTGGCTGGACTC
GGCATCGGCTATGTCGATGCCCACTTGCTGGCGTCCACTCGGCTGACCGCCGGATCGACCCTCTGGAGCCGTGACAAGCG
GCTTGCCCGCGTTGCCGAGCGACTGGAACTGGCCTGGCAGGGTGGACTTTTGCCGCCCCCTTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7309.56 Da        Isoelectric Point: 10.9368

>AT56421 WP_019403242.1 NZ_CP012398:130365-130562 [Chelatococcus sp. CO-6]
MRMTVALDDDLLAKAQAFTGLKETSALMREALKALIERESARRLARLGGTEPDLEIAPRRRMTPR

Download         Length: 198 bp

>AT56421 NZ_CP012398:130365-130562 [Chelatococcus sp. CO-6]
ATGCGCATGACCGTGGCCCTTGATGATGATCTTCTGGCGAAGGCTCAGGCCTTCACCGGCCTCAAGGAAACGTCCGCCCT
CATGCGAGAGGCGCTCAAGGCGCTGATCGAGCGGGAAAGCGCACGCCGTCTCGCCCGTCTCGGCGGCACCGAACCTGATC
TTGAGATTGCACCGCGGCGGCGTATGACGCCCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A840C5N9

Antitoxin

Source ID Structure
AlphaFold DB A0A840C454

References