Detailed information of TA system TA056414

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1056375..1057808
• Replicon: chromosome
• Accession: NZ_CP012387
• Organism: Mycoplasma mycoides subsp. capri strain GM12

Toxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: AB128_RS04400
• Protein ID: WP_080511208.1
• Coordinates: 1056375..1057109 (-)
• Length: 245 a.a.

Antitoxin (Protein)

• Gene name: abiEi
• Uniprot ID: A0A7Z7PN10
• Locus tag: AB128_RS04405
• Protein ID: WP_020863064.1
• Coordinates: 1057209..1057808 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB128_RS04385	1052671..1054248	-	1578	WP_020863062.1	dicarboxylate/amino acid:cation symporter	-
AB128_RS04390	1054268..1055611	-	1344	WP_023905986.1	CoA-disulfide reductase	-
AB128_RS04395	1055829..1056329	+	501	WP_020863063.1	isochorismatase family protein	-
AB128_RS04400	1056375..1057109	-	735	WP_080511208.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
AB128_RS04405	1057209..1057808	-	600	WP_020863064.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
AB128_RS04975	1058076..1058195	+	120	Protein_836	isochorismatase family protein	-
AB128_RS04410	1058385..1059719	+	1335	WP_020863065.1	DUF285 domain-containing protein	-
AB128_RS05080	1059969..1061192	+	1224	WP_020863066.1	phosphatase PAP2 family protein	-
AB128_RS04420	1061323..1062528	+	1206	WP_020863067.1	phosphatase PAP2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (4-210)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (5-53)

Sequences

Toxin

Protein

• Length: 245 a.a.
• Molecular weight: 28915.65 Da
• Isoelectric Point: 9.5052

>T56414 WP_080511208.1 NZ_CP012387:c1057109-1056375 [Mycoplasma mycoides subsp. capri]
MKKISKNKDKINIIFKGGFLLSNIIGIKERTTKDIDYLLNNIVFSPDRIKELFEDILDYKKGDKIHFQIQKINEIKKKEK
YTGFRITVECKLDEIVEIIKIDVATGDIITSCQVRYNIENIFHNNSFYVYGYNLETMLAEKIHAIKELSLFNTRTKDFYD
IYLIYNLKRDDIDYMTLKNACINTFKQRNSIFDKDDLLELLNKIKNSQSTHNLTKQKNIYFYNKNIDFKFIIQSIIELIK
NIK

Nucleotide

• Length: 735 bp

>T56414 NZ_CP012387:c1057109-1056375 [Mycoplasma mycoides subsp. capri]
CTGAAAAAAATATCTAAGAATAAGGATAAGATAAATATCATATTTAAAGGAGGTTTTTTGCTTTCTAATATAATTGGAAT
AAAAGAAAGAACAACCAAAGATATTGATTATTTATTAAATAACATTGTATTTTCACCTGATCGTATAAAAGAATTATTTG
AAGATATTTTAGATTATAAGAAAGGAGATAAAATACATTTTCAAATTCAAAAAATAAATGAAATTAAGAAAAAAGAAAAA
TATACAGGTTTTAGAATAACTGTAGAATGCAAATTAGATGAAATAGTAGAAATTATAAAAATAGATGTAGCAACAGGTGA
TATCATCACTTCCTGTCAAGTTAGATATAATATTGAAAATATTTTTCATAACAACAGTTTTTATGTTTATGGTTATAACT
TAGAAACTATGTTGGCTGAAAAAATTCATGCAATCAAAGAATTAAGCTTGTTTAATACTAGAACAAAAGATTTCTATGAT
ATATACCTAATTTATAATTTAAAAAGAGATGATATTGACTATATGACGTTGAAAAATGCTTGTATTAATACATTCAAACA
AAGAAACAGCATTTTTGATAAAGACGATTTATTAGAGTTACTCAATAAAATAAAAAATTCGCAATCTACTCATAATTTAT
GAACTAAACAAAAAAATATATATTTTTATAATAAAAACATAGATTTTAAATTTATCATTCAGTCAATTATTGAACTTATT
AAAAACATTAAATAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 23847.67 Da
• Isoelectric Point: 8.3457

>AT56414 WP_020863064.1 NZ_CP012387:c1057808-1057209 [Mycoplasma mycoides subsp. capri]
MNYVEKIKEKAIQNNGLITRKEIISLKIPPIYITRMVRKKELEKIDIGIYALTSLDNYPYDPEFNFCSRYQVPVFSYVYA
LNLFDFTDVIPLNFEVTVYKGYNAHNLKPNTIVHYVNKEIFNLGITEIRNAFGNWVRTYDIERTICDLIKNRKNINVELF
VKTMNNYVNYEKKDWNKLYEYAEKMHIEKELVEIFQLII

Nucleotide

• Length: 600 bp

>AT56414 NZ_CP012387:c1057808-1057209 [Mycoplasma mycoides subsp. capri]
ATGAACTATGTAGAAAAAATAAAAGAAAAAGCCATTCAAAATAATGGACTAATAACAAGAAAAGAAATTATAAGTCTAAA
AATCCCACCTATTTATATAACTAGAATGGTAAGAAAAAAAGAACTTGAAAAAATTGATATTGGAATTTATGCACTAACTT
CACTAGATAATTATCCTTACGATCCCGAATTTAATTTTTGTTCAAGATATCAAGTTCCTGTTTTTTCATATGTTTATGCA
TTAAACTTATTTGATTTTACTGATGTTATTCCACTTAATTTTGAAGTAACTGTTTATAAAGGGTATAATGCACATAATCT
TAAACCTAACACAATAGTTCACTATGTTAATAAAGAAATTTTTAATCTAGGAATTACTGAAATTAGAAATGCTTTTGGAA
ATTGGGTAAGAACCTATGATATTGAAAGAACAATTTGTGATCTTATTAAAAATAGAAAAAATATTAATGTTGAACTTTTT
GTAAAAACTATGAATAACTATGTTAATTATGAAAAAAAGGACTGGAATAAACTTTATGAATATGCTGAAAAAATGCACAT
TGAAAAAGAGCTAGTAGAAATATTTCAACTTATTATTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7Z7PN10