Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 246223..247021 Replicon chromosome
Accession NZ_CP012379
Organism Escherichia coli strain PAR

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag AKO63_RS01195 Protein ID WP_000854730.1
Coordinates 246223..246600 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag AKO63_RS01200 Protein ID WP_001285482.1
Coordinates 246647..247021 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AKO63_RS01170 242257..242548 + 292 Protein_217 transposase -
AKO63_RS01175 242545..242895 + 351 WP_094058131.1 IS66 family insertion sequence element accessory protein TnpB -
AKO63_RS01180 242926..244519 + 1594 Protein_219 IS66 family transposase -
AKO63_RS01185 244667..245655 + 989 Protein_220 IS630 family transposase -
AKO63_RS01190 245734..246226 - 493 Protein_221 hypothetical protein -
AKO63_RS01195 246223..246600 - 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
AKO63_RS01200 246647..247021 - 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AKO63_RS01205 247071..247715 - 645 WP_000086759.1 hypothetical protein -
AKO63_RS01210 247734..247955 - 222 WP_000692315.1 DUF987 domain-containing protein -
AKO63_RS01215 248018..248494 - 477 WP_001313574.1 RadC family protein -
AKO63_RS01220 248510..248983 - 474 WP_001313575.1 antirestriction protein -
AKO63_RS01225 249077..249322 - 246 WP_001164966.1 hypothetical protein -
AKO63_RS01230 249322..250143 - 822 WP_001234359.1 DUF945 domain-containing protein -
AKO63_RS01235 250243..250476 - 234 WP_001213776.1 DUF905 family protein -
AKO63_RS01240 250594..251046 - 453 WP_000682723.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T56359 WP_000854730.1 NZ_CP012379:c246600-246223 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T56359 NZ_CP012379:c246600-246223 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCTTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCATCCGGGGTGAACATTCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT56359 WP_001285482.1 NZ_CP012379:c247021-246647 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT56359 NZ_CP012379:c247021-246647 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References