Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 3966937..3967334 Replicon chromosome
Accession NZ_CP012375
Organism Microcystis aeruginosa NIES-2481

Toxin (Protein)


Gene name vapC Uniprot ID A0A6H9FK19
Locus tag amyaer_RS19525 Protein ID WP_071846506.1
Coordinates 3966937..3967134 (-) Length 66 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag amyaer_RS19530 Protein ID WP_046663291.1
Coordinates 3967131..3967334 (-) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
amyaer_RS19505 3963182..3964093 + 912 WP_046663289.1 heme A synthase -
amyaer_RS19510 3964245..3965195 + 951 WP_008202059.1 heme o synthase -
amyaer_RS19515 3965288..3966622 - 1335 WP_046663290.1 chromosomal replication initiator protein DnaA -
amyaer_RS19520 3966707..3966940 + 234 Protein_3707 peptide deformylase -
amyaer_RS19525 3966937..3967134 - 198 WP_071846506.1 DUF5615 family PIN-like protein Toxin
amyaer_RS19530 3967131..3967334 - 204 WP_046663291.1 DUF433 domain-containing protein Antitoxin
amyaer_RS19540 3967670..3967894 + 225 WP_071846507.1 hypothetical protein -
amyaer_RS19545 3968009..3968614 - 606 WP_045360674.1 DedA family protein -
amyaer_RS19550 3968706..3969983 - 1278 WP_002732258.1 adenosylhomocysteinase -
amyaer_RS19555 3970128..3970799 - 672 WP_046663297.1 riboflavin synthase -
amyaer_RS19560 3970815..3972110 - 1296 WP_046663298.1 glutamate-5-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(1-63)

Antitoxin

Protein of unknown function DUF433

(1-56)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7240.27 Da        Isoelectric Point: 4.3138

>T56332 WP_071846506.1 NZ_CP012375:c3967134-3966937 [Microcystis aeruginosa NIES-2481]
MTIWVDAHLSPAIATRISTKLEIEAVALRDLGPRDAEDTEIFQVAKAQRAIVMTKDSDFVDLVEQ

Download         Length: 198 bp

>T56332 NZ_CP012375:c3967134-3966937 [Microcystis aeruginosa NIES-2481]
ATGACAATTTGGGTTGACGCACATTTGTCTCCTGCAATTGCAACCCGGATTAGCACTAAACTTGAGATTGAAGCTGTGGC
CTTGCGTGATCTTGGACCCAGAGATGCTGAAGATACTGAAATCTTTCAGGTTGCAAAAGCTCAAAGAGCTATCGTAATGA
CCAAAGACAGCGATTTTGTAGATTTAGTTGAGCAGTGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7073.26 Da        Isoelectric Point: 5.7055

>AT56332 WP_046663291.1 NZ_CP012375:c3967334-3967131 [Microcystis aeruginosa NIES-2481]
ITVNPRQCGGRACIRGMRILGSDVLALFAAGLSAGEILDEIPDLEADDLKAALLYASRKLNHPVLVA

Download         Length: 204 bp

>AT56332 NZ_CP012375:c3967334-3967131 [Microcystis aeruginosa NIES-2481]
ATTACAGTTAATCCTCGGCAGTGCGGTGGTCGTGCCTGTATTCGAGGAATGAGAATCCTGGGATCAGATGTGTTAGCTCT
ATTCGCGGCAGGTTTAAGTGCGGGAGAAATTCTAGATGAAATACCTGATCTTGAGGCAGATGATTTGAAAGCAGCGCTTT
TATATGCCTCACGGAAGCTTAATCACCCAGTTTTAGTGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6H9FK19

Antitoxin

Source ID Structure

References