Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-UPF0150
Location 2722815..2723248 Replicon chromosome
Accession NZ_CP012375
Organism Microcystis aeruginosa NIES-2481

Toxin (Protein)


Gene name hicA Uniprot ID A0A0F6U4V0
Locus tag amyaer_RS13425 Protein ID WP_046662457.1
Coordinates 2723024..2723248 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L7EDS5
Locus tag amyaer_RS13420 Protein ID WP_002734412.1
Coordinates 2722815..2723027 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
amyaer_RS13400 2718343..2720514 - 2172 WP_046662456.1 glutamine synthetase III -
amyaer_RS13405 2720929..2721825 + 897 WP_046663771.1 PEP-CTERM sorting domain-containing protein -
amyaer_RS13410 2721882..2722154 - 273 WP_012264430.1 Txe/YoeB family addiction module toxin -
amyaer_RS13415 2722138..2722437 - 300 WP_002763657.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
amyaer_RS13420 2722815..2723027 + 213 WP_002734412.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
amyaer_RS13425 2723024..2723248 + 225 WP_046662457.1 type II toxin-antitoxin system HicA family toxin Toxin
amyaer_RS13430 2723326..2723598 + 273 WP_002773681.1 hypothetical protein -
amyaer_RS13440 2723962..2724207 + 246 WP_002753457.1 type II toxin-antitoxin system HicB family antitoxin -
amyaer_RS13445 2724207..2724428 + 222 WP_002732388.1 type II toxin-antitoxin system HicA family toxin -
amyaer_RS13450 2724525..2725961 - 1437 WP_046662458.1 folate/biopterin family MFS transporter -
amyaer_RS13460 2726510..2727154 - 645 WP_046662460.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(9-65)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-62)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8365.88 Da        Isoelectric Point: 11.2578

>T56328 WP_046662457.1 NZ_CP012375:2723024-2723248 [Microcystis aeruginosa NIES-2481]
MSELPPIAGRQVVKALGKIGYELDRQRGSHIILRQKAYPYRRITIPDHREVAKGALRSIIRQAGLTVAEFKTLL

Download         Length: 225 bp

>T56328 NZ_CP012375:2723024-2723248 [Microcystis aeruginosa NIES-2481]
ATGAGTGAACTCCCTCCTATCGCTGGTCGCCAAGTCGTTAAAGCACTAGGCAAGATTGGCTACGAATTAGATCGGCAGCG
AGGAAGTCATATCATACTCAGACAAAAAGCCTATCCCTATCGACGCATCACCATCCCTGACCATCGAGAAGTGGCTAAGG
GAGCACTGAGATCTATCATTCGTCAAGCGGGATTGACAGTGGCAGAGTTTAAAACTCTCCTTTAG

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7818.89 Da        Isoelectric Point: 3.8618

>AT56328 WP_002734412.1 NZ_CP012375:2722815-2723027 [Microcystis aeruginosa NIES-2481]
MKYRVLIEQDEDGIYVAEVPSLPGCISQGNTREELLANIQEAIALYLESLEAHNEPIPPPISEELVEVKL

Download         Length: 213 bp

>AT56328 NZ_CP012375:2722815-2723027 [Microcystis aeruginosa NIES-2481]
ATGAAATATCGCGTCTTAATTGAGCAAGATGAAGATGGCATTTATGTGGCTGAAGTTCCCTCCCTACCCGGCTGTATTTC
TCAAGGCAATACCCGGGAAGAGTTACTCGCCAACATTCAGGAAGCAATTGCTTTATATCTAGAAAGCCTAGAAGCGCACA
ATGAACCGATTCCACCACCAATTTCTGAGGAACTGGTAGAGGTTAAATTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6U4V0

Antitoxin

Source ID Structure
AlphaFold DB L7EDS5

References