Detailed information of TA system TA056320

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2685708..2686295
• Replicon: chromosome
• Accession: NZ_CP012371
• Organism: Nitrosospira briensis C-128

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: F822_RS14950
• Protein ID: WP_036575826.1
• Coordinates: 2686119..2686295 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: F822_RS12190
• Protein ID: WP_025041002.1
• Coordinates: 2685708..2686109 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F822_RS12150	2680812..2683109	-	2298	WP_025041010.1	PriCT-2 domain-containing protein	-
F822_RS12155	2683112..2683609	-	498	WP_025041009.1	hypothetical protein	-
F822_RS12165	2683865..2684113	-	249	WP_025041007.1	hypothetical protein	-
F822_RS12170	2684110..2684307	-	198	WP_025041006.1	hypothetical protein	-
F822_RS12175	2684370..2684918	+	549	WP_156304418.1	hypothetical protein	-
F822_RS12180	2684915..2685157	+	243	WP_025041004.1	hypothetical protein	-
F822_RS12185	2685206..2685619	+	414	WP_025041003.1	hypothetical protein	-
F822_RS12190	2685708..2686109	-	402	WP_025041002.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
F822_RS14950	2686119..2686295	-	177	WP_036575826.1	type II toxin-antitoxin system HicA family toxin	Toxin
F822_RS12195	2686777..2686992	+	216	WP_025041001.1	hypothetical protein	-
F822_RS12200	2687010..2687258	+	249	WP_025041000.1	hypothetical protein	-
F822_RS12205	2687276..2687617	+	342	WP_025040999.1	hypothetical protein	-
F822_RS12210	2687607..2687903	+	297	WP_025040998.1	hypothetical protein	-
F822_RS12215	2687900..2689777	+	1878	WP_025040997.1	ParB/RepB/Spo0J family partition protein	-
F822_RS12220	2689774..2690352	+	579	WP_025040996.1	hypothetical protein	-
F822_RS12225	2690331..2690606	+	276	WP_025040995.1	hypothetical protein	-
F822_RS12230	2690625..2691095	+	471	WP_025040994.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2648929..2701927	52998

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-125)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6463.63 Da
• Isoelectric Point: 10.8877

>T56320 WP_036575826.1 NZ_CP012371:c2686295-2686119 [Nitrosospira briensis C-128]
MNSKQLMQLLKDNGFEIDRIKGSHHQMKKDGRTVTVPHPKKDLGVGLVNAILKQAGLK

Nucleotide

• Length: 177 bp

>T56320 NZ_CP012371:c2686295-2686119 [Nitrosospira briensis C-128]
ATGAACAGCAAACAACTCATGCAGCTCTTAAAAGACAACGGTTTCGAGATAGACCGTATCAAGGGCAGCCATCATCAGAT
GAAGAAAGACGGCAGAACGGTGACAGTGCCGCACCCTAAAAAGGATTTGGGAGTTGGTTTGGTGAATGCGATTTTGAAAC
AGGCGGGATTAAAGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14749.71 Da
• Isoelectric Point: 4.8362

>AT56320 WP_025041002.1 NZ_CP012371:c2686109-2685708 [Nitrosospira briensis C-128]
MRYPIAIEMGDESHSCGVVVPDLPGCFSAGDTVDEAITNAHEAVLLHLETYLDEGRAFPKPLPIEEHRKNPEFDGWIWAM
VSVDLSQLDDKVERVNITLPKRVLRVIDEGAKRSGESRSAFLAKAGIEAARHQ

Nucleotide

• Length: 402 bp

>AT56320 NZ_CP012371:c2686109-2685708 [Nitrosospira briensis C-128]
ATGCGTTATCCGATAGCGATTGAAATGGGGGATGAGTCACACTCATGCGGCGTGGTGGTGCCCGATTTGCCCGGTTGCTT
TTCAGCGGGCGATACGGTGGACGAGGCCATAACGAATGCGCATGAAGCGGTATTGCTTCACCTGGAAACCTATCTGGATG
AAGGCCGGGCTTTTCCCAAACCGCTCCCCATTGAAGAACACAGGAAAAATCCTGAGTTTGACGGCTGGATCTGGGCAATG
GTAAGTGTCGATTTATCGCAGCTCGATGACAAGGTGGAGCGCGTCAACATAACTCTACCGAAGCGGGTATTGAGGGTTAT
TGACGAAGGCGCGAAACGATCCGGTGAGTCGCGCTCGGCTTTCTTGGCCAAGGCTGGGATAGAGGCTGCACGGCACCAAT
AG