Detailed information of TA system TA056319

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-MazE
• Location: 1900603..1901230
• Replicon: chromosome
• Accession: NZ_CP012371
• Organism: Nitrosospira briensis C-128

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: F822_RS08670
• Protein ID: WP_025042173.1
• Coordinates: 1900823..1901230 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: F822_RS08665
• Protein ID: WP_025042174.1
• Coordinates: 1900603..1900836 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F822_RS08650	1895796..1898630	-	2835	WP_025042176.1	isoleucine--tRNA ligase	-
F822_RS08655	1898655..1899656	-	1002	WP_025042175.1	bifunctional riboflavin kinase/FAD synthetase	-
F822_RS14870	1900202..1900443	+	242	Protein_1690	DUF4102 domain-containing protein	-
F822_RS08665	1900603..1900836	+	234	WP_025042174.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
F822_RS08670	1900823..1901230	+	408	WP_025042173.1	PIN domain-containing protein	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-116)

Antitoxin

• SpoVT-AbrB domain (5-46)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14863.24 Da
• Isoelectric Point: 4.8836

>T56319 WP_025042173.1 NZ_CP012371:1900823-1901230 [Nitrosospira briensis C-128]
MPAPKAFIDSNILLYLLSADADKANRAEEIVRAGGLISVQVLNEITNVARRKLAMSWVEINEVLGLIRSICPTEPLTIET
HDRGRLVAERYGLSVYDAMIVAAAILAGCKTLYSEDMQDGLLIDHQLHICNPFQA

Nucleotide

• Length: 408 bp

>T56319 NZ_CP012371:1900823-1901230 [Nitrosospira briensis C-128]
ATGCCCGCCCCTAAAGCCTTTATTGACAGCAATATTTTGCTGTACCTTTTATCGGCTGATGCTGATAAGGCCAATCGGGC
TGAGGAAATTGTGCGGGCAGGCGGGCTAATCAGCGTACAGGTGTTAAACGAGATAACGAATGTAGCACGTCGTAAGCTCG
CCATGTCGTGGGTGGAAATCAATGAAGTGTTAGGCCTGATCCGGTCGATATGTCCAACCGAGCCGTTGACTATCGAGACC
CATGATCGAGGTAGGCTTGTCGCTGAGCGATATGGGCTAAGCGTATATGATGCAATGATCGTAGCGGCTGCAATTCTTGC
AGGATGCAAGACATTATATTCAGAGGACATGCAGGACGGGCTACTGATCGACCATCAGTTGCATATTTGTAATCCATTCC
AGGCTTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8810.11 Da
• Isoelectric Point: 5.8507

>AT56319 WP_025042174.1 NZ_CP012371:1900603-1900836 [Nitrosospira briensis C-128]
MQVSKWGNSLAIRLPASVVEALELHEGDDIEVVIADERVFQVKKKPGNDAFLMRLREFRGKLPVDFKFDRDEANARP

Nucleotide

• Length: 234 bp

>AT56319 NZ_CP012371:1900603-1900836 [Nitrosospira briensis C-128]
ATGCAAGTCTCAAAGTGGGGTAATAGCTTGGCAATTCGATTGCCTGCCTCAGTGGTTGAAGCACTGGAACTACACGAAGG
CGACGACATTGAAGTGGTGATTGCTGATGAACGGGTTTTCCAAGTGAAAAAGAAACCCGGCAACGATGCCTTTCTGATGC
GATTACGAGAATTCAGGGGGAAGCTCCCTGTTGATTTCAAGTTTGACCGCGACGAAGCAAATGCCCGCCCCTAA