56316

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1043567..1044141 Replicon chromosome
Accession NZ_CP012370
Organism Moorella thermoacetica strain DSM 2955

Toxin (Protein)


Gene name mazF Uniprot ID A0A0S6UGS1
Locus tag MOTHA_RS05235 Protein ID WP_011392535.1
Coordinates 1043794..1044141 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1D7X9U1
Locus tag MOTHA_RS05230 Protein ID WP_053094734.1
Coordinates 1043567..1043800 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOTHA_RS05210 1038585..1038839 - 255 WP_011392529.1 DUF3243 domain-containing protein -
MOTHA_RS05215 1039131..1039817 - 687 WP_011392530.1 manganese catalase family protein -
MOTHA_RS05220 1040300..1040533 + 234 WP_139560391.1 hypothetical protein -
MOTHA_RS13240 1040517..1040780 + 264 WP_011392531.1 type II toxin-antitoxin system RelE/ParE family toxin -
MOTHA_RS05225 1041853..1043268 + 1416 WP_162490286.1 YdcF family protein -
MOTHA_RS05230 1043567..1043800 + 234 WP_053094734.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MOTHA_RS05235 1043794..1044141 + 348 WP_011392535.1 endoribonuclease MazF Toxin
MOTHA_RS05240 1044492..1046021 + 1530 WP_011392536.1 YifB family Mg chelatase-like AAA ATPase -
MOTHA_RS05245 1046175..1046699 + 525 WP_011392537.1 hypothetical protein -
MOTHA_RS05250 1046889..1047989 + 1101 WP_011392538.1 iron-containing alcohol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-47)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12605.71 Da        Isoelectric Point: 7.8219

>T56316 WP_011392535.1 NZ_CP012370:1043794-1044141 [Moorella thermoacetica]
MVNEMETYIPERGDIVWLQFDPRAGHEQAGRRPALVISPQLYNGKVGLALFCPVTTKAKGYPFEVEIPAGLKITGVILAD
QVKSLDWRAREAQFACKVPAGVVAEVQAKVQVLIS

Download         Length: 348 bp

>T56316 NZ_CP012370:1043794-1044141 [Moorella thermoacetica]
ATGGTAAACGAGATGGAAACCTATATTCCCGAACGTGGTGATATAGTCTGGCTCCAGTTTGATCCTCGGGCAGGACATGA
GCAAGCTGGCAGGCGGCCGGCGCTGGTAATTTCACCGCAACTTTATAACGGCAAAGTGGGACTGGCCCTTTTTTGCCCAG
TTACTACAAAGGCGAAGGGTTATCCCTTTGAAGTAGAGATACCGGCTGGTTTAAAGATTACCGGAGTGATCCTGGCAGAC
CAGGTAAAAAGCCTTGACTGGCGGGCAAGGGAGGCGCAATTTGCCTGTAAAGTCCCGGCAGGGGTGGTAGCAGAAGTCCA
GGCTAAAGTTCAGGTGTTGATTTCCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8798.14 Da        Isoelectric Point: 7.2029

>AT56316 WP_053094734.1 NZ_CP012370:1043567-1043800 [Moorella thermoacetica]
MQPHVQKWGNSLGIRIPLSLAQKIGLREGTPVDLQVDEDAIIIRRKQYSLEQMLARVKPENIHSEIDTGPQVGREIW

Download         Length: 234 bp

>AT56316 NZ_CP012370:1043567-1043800 [Moorella thermoacetica]
ATGCAACCTCATGTGCAAAAGTGGGGCAATAGTTTAGGGATACGTATCCCTTTGTCGCTAGCCCAAAAAATCGGCCTTAG
AGAAGGCACACCGGTTGATTTACAGGTAGATGAGGATGCGATAATTATCCGCCGCAAACAATACAGCCTGGAACAAATGT
TAGCCCGGGTTAAACCTGAAAATATTCATAGTGAAATAGATACCGGGCCTCAGGTTGGGCGGGAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S6UGS1

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7X9U1

References