Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 2405258..2405777 Replicon chromosome
Accession NZ_CP012366
Organism Enterococcus durans strain KLDS 6.0933

Toxin (Protein)


Gene name Txe Uniprot ID A0A377L4K5
Locus tag LIANG_RS11435 Protein ID WP_005878588.1
Coordinates 2405520..2405777 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID A0A367CD15
Locus tag LIANG_RS11430 Protein ID WP_005878590.1
Coordinates 2405258..2405527 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIANG_RS11400 (LIANG_11400) 2400382..2401269 + 888 WP_005878604.1 site-specific tyrosine recombinase XerD -
LIANG_RS11405 (LIANG_11405) 2401288..2401659 + 372 WP_005878601.1 GNAT family N-acetyltransferase -
LIANG_RS11410 (LIANG_11410) 2401656..2402426 + 771 WP_025479929.1 segregation/condensation protein A -
LIANG_RS11415 (LIANG_11415) 2402410..2402985 + 576 WP_016176830.1 SMC-Scp complex subunit ScpB -
LIANG_RS11420 (LIANG_11420) 2402985..2403701 + 717 WP_005878594.1 pseudouridine synthase -
LIANG_RS11425 (LIANG_11425) 2404033..2404641 + 609 WP_005878592.1 ECF transporter S component -
LIANG_RS15405 2405054..2405200 + 147 WP_155854551.1 hypothetical protein -
LIANG_RS11430 (LIANG_11430) 2405258..2405527 + 270 WP_005878590.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LIANG_RS11435 (LIANG_11435) 2405520..2405777 + 258 WP_005878588.1 Txe/YoeB family addiction module toxin Toxin
LIANG_RS11440 (LIANG_11440) 2405912..2407207 - 1296 WP_016176443.1 ISL3 family transposase -
LIANG_RS11445 (LIANG_11445) 2407653..2408252 + 600 WP_229090134.1 hypothetical protein -
LIANG_RS11450 (LIANG_11450) 2408267..2408713 + 447 WP_016176828.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2405912..2407207 1295


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10274.61 Da        Isoelectric Point: 9.2515

>T56311 WP_005878588.1 NZ_CP012366:2405520-2405777 [Enterococcus durans]
MIKAWSDDAWNDYLYWYEQGNKSNIKKINKLIKDIDRSPFNGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T56311 NZ_CP012366:2405520-2405777 [Enterococcus durans]
ATGATTAAGGCATGGTCTGATGACGCATGGAACGATTATCTTTATTGGTATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAATAAATTGATAAAAGACATTGATCGTTCCCCTTTTAATGGATTAGGAAAGCCTGAGCCGTTAAAGCACGATTTAT
CTGGGAAATGGTCAAGAAGAATTACAGATGAACACAGACTGATATATAGAGTTGAAAATGAAACGATATTTATCTATTCT
GCAAAAGACCATTATTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10402.60 Da        Isoelectric Point: 4.7051

>AT56311 WP_005878590.1 NZ_CP012366:2405258-2405527 [Enterococcus durans]
MEAVSYSNFRKNLRGYMKQVNEDAETLIVTSKDVDDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGTFKKH
DLIEVESDD

Download         Length: 270 bp

>AT56311 NZ_CP012366:2405258-2405527 [Enterococcus durans]
ATGGAAGCAGTATCTTATTCAAACTTCCGAAAAAATTTGCGTGGTTATATGAAACAAGTAAATGAAGATGCTGAAACACT
TATCGTAACAAGTAAAGATGTTGATGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACATTGA
GAACACTTTCTAACAATTACGTGATGGAAAAAATTCGTAGAGGGGACGAACAGTTTTCAAAAGGTACATTTAAGAAACAT
GACTTAATTGAGGTCGAATCTGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377L4K5

Antitoxin

Source ID Structure
AlphaFold DB A0A367CD15

References